Apigenin 4'-O-methyltransferase

In enzymology, an apigenin 4'-O-methyltransferase (EC 2.1.1.75) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone
apigenin 4'-O-methyltransferase
Identifiers
EC no.2.1.1.75
CAS no.118251-36-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are S-adenosyl methionine and 5,7,4'-trihydroxyflavone (apigenin), whereas its two products are S-adenosylhomocysteine and 4'-methoxy-5,7-dihydroxyflavone (acacetin).

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:5,7,4'-trihydroxyflavone 4'-O-methyltransferase. Other names in common use include flavonoid O-methyltransferase, and flavonoid methyltransferase. This enzyme participates in flavonoid biosynthesis.

References

    • Kuroki G, Poulton JE (1981). "The para-O-methylation of apigenin to acacetin by cell-free extracts of Robinia pseudoacacia L". Z. Naturforsch. C: Biosci. 36: 916–920.


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