Arachidonate—CoA ligase

In enzymology, an arachidonate—CoA ligase (EC 6.2.1.15) is an enzyme that catalyzes the chemical reaction

ATP + arachidonate + CoA AMP + diphosphate + arachidonoyl-CoA
Arachidonate—CoA ligase
Identifiers
EC no.6.2.1.15
CAS no.82047-87-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

The 3 substrates of this enzyme are ATP, arachidonate, and CoA, whereas its 3 products are AMP, diphosphate, and arachidonoyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is arachidonate:CoA ligase (AMP-forming). This enzyme is also called arachidonoyl-CoA synthetase.

References

    • Wilson DB, Prescott SM, Majerus PW (1982). "Discovery of an arachidonoyl coenzyme A synthetase in human platelets". J. Biol. Chem. 257 (7): 3510–5. PMID 7061494.


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