Ary L. Goldberger

Ary Louis Goldberger (b. Bronx, New York City, May 29, 1949) is a physician-educator, whose collaborative research work is at the interface of biomedicine and complexity science (nonlinear dynamics).[1][2] He holds a BA from Harvard College and an MD from Yale Medical School. He did his clinical training in internal medicine and cardiovascular disease at Yale–New Haven Hospital and at the University of California, San Diego, respectively. He currently serves as Professor of Medicine at Harvard Medical School[3] and was one of the Core Founding Faculty (2010-2015) of the Wyss Institute for Biologically Inspired Engineering at Harvard University.[4]

Ary Louis Goldberger
Born(1949-05-05)May 5, 1949
Bronx, New York City
Alma materHarvard College, Yale Medical School
Known forPhysioNet
Scientific career
InstitutionsHarvard University, Beth Israel Deaconess Medical Center

Research

Goldberger is founding and current Principal Investigator (with R. G. Mark at MIT) of the NIH-sponsored Research Resource for Complex Physiologic Signals.[5] The “Big Data” PhysioNet Resource is the first and remains the largest repository of free, open-access databases and open-source computational tools devoted to complex signals informatics. In addition, he is founding and current Director of the Margret and H.A. Rey Institute for Nonlinear Dynamics in Physiology and Medicine at Beth Israel Deaconess Medical Center (BIDMC) in Boston.[6][7]

Publications

Goldberger is the senior author of two textbooks on clinical electrocardiography.[8][9][10] He and his colleagues at BIDMC are developers of ECG Wave-Maven,[11] the largest and most–widely used free teaching site for ECG self-assessment. He is also co-author of a recent book on critical thinking for students of medicine and their mentors.[12]

Honors

His scientific investigations focus on nonlinear mechanisms of healthy function and their alterations with pathology. He and his colleagues were the first to identify the fractal dynamics of the healthy heartbeat and describe alterations in fractal scaling with life-threatening conditions such as heart failure.[13][14][15] Goldberger and colleagues originated and continue to elaborate the complexity-loss theory of aging and disease[16][17][18][19][20][21] which is widely cited in basic science and clinical research.

Some of this work was featured on the 2011 PBS-NOVA show: Hunting the Hidden Dimension. Among other honors, he is a recipient of the S. Robert Stone Award for Excellence in Teaching at Harvard Medical School/BIDMC and an Ellison Medical Foundation Senior Scholar in Aging Award.

Goldberger and colleagues, R.G Mark and G.B. Moody, are recipients of the 2016 Laufman-Greatbatch Award from the Association for the Advancement of Medical Instrumentation (AAMI). This honor, the highest conferred by the AAMI Foundation, recognizes work over the last 20 years to collect and provide open access to “big data” and software tools through the creation of the PhysioNet Resource.[22]

References
  1. Goldberger AL, Rigney DR, West BJ (1990), "Chaos and fractals in human physiology" (PDF), Sci Am, 262 (2): 42–9, doi:10.1038/scientificamerican0290-42, PMID 2296715
  2. Goldberger A.L. (2006), "Giles F. Filley Lecture. Complex Systems.", Proceedings of the American Thoracic Society, 3 (6): 467–71, doi:10.1513/pats.200603-028MS, PMC 2647633, PMID 16921107
  3. "Ary Louis Goldberger, M.D." Harvard Catalyst Profiles. Archived from the original on 2014-06-05. Retrieved 3 June 2020.
  4. "Ary Goldberger, M.D." Wyss Institute. Archived from the original on 2009-10-10. Retrieved 3 June 2020.
  5. PhysioNet
  6. ReyLab
  7. "Ary Goldberger, M.D." Margret and H.A. Rey Institute. Archived from the original on 2006-09-01. Retrieved 3 June 2020.
  8. Henning, Robert J. (1976). "Myocardial Infarction: Electrocardiographic Differential Diagnosis". JAMA: The Journal of the American Medical Association. 235 (26): 2865. doi:10.1001/jama.1976.03260520057033. ISSN 0098-7484.
  9. Goldberger AL (1991). Myocardial Infarction: Electrocardiographic Differential Diagnosis (4th ed.). St. Louis: Mosby-Year Book. ISBN 9780801618567.
  10. Goldberger AL, Goldberger ZD, Shvilkin A (2012). Goldberger's Clinical Electrocardiography: A Simplified Approach (8th ed.). Philadelphia: Elsevier. ISBN 9780323087865.
  11. ECG Wave-Maven
  12. McMahon, Eimear; Brian Hallahan (May 2013). "Review of 'Becoming a consummate clinician – what every student, house officer and hospital practitioner needs to know' (review)". Irish Journal of Psychological Medicine. 30 (2): 160–161. doi:10.1017/ipm.2013.11.
  13. Goldberger AL, Bhargava V, West BJ, Mandell AJ (1985), "On a mechanism of cardiac electrical stability. The fractal hypothesis.", Biophys J, 48 (3): 525–8, Bibcode:1985BpJ....48..525G, doi:10.1016/s0006-3495(85)83808-x, ISSN 0006-3495, PMC 1329366, PMID 4041542
  14. Goldberger AL, West BJ (1987), "Fractals in physiology and medicine", Yale J Biol Med, 60 (5): 421–35, ISSN 0044-0086, PMC 2590346, PMID 3424875
  15. Goldberger AL; Amaral LAN; Hausdorff JM; Ivanov PCh; Peng CK; Stanley HE (2002), "Fractal dynamics in physiology: alterations with disease and aging.", Proc Natl Acad Sci USA, 99 (Suppl 1): 2466–2472, Bibcode:2002PNAS...99.2466G, doi:10.1073/pnas.012579499, ISSN 0027-8424, PMC 128562, PMID 11875196
  16. Goldberger AL, Findley L, Blackburn MJ, Mandell AJ (1984), "Nonlinear dynamics of heart failure: implications of long-wavelength cardiopulmonary oscillations.", Am Heart J, 107 (3): 612–5, doi:10.1016/0002-8703(84)90120-0, ISSN 0002-8703, PMID 6695715
  17. Goldberger A.L. (1996), "Fractals and the birth of Gothic: reflections on the biologic basis of creativity", Molecular Psychiatry, 1 (2): 99–104, ISSN 1359-4184, PMID 9118332
  18. Lipsitz LA, Goldberger AL (1992), "Loss of "complexity" and aging. Potential applications of fractals and chaos theory to senescence.", JAMA, 267 (13): 1806–09, doi:10.1001/jama.1992.03480130122036, ISSN 0098-7484, PMID 1482430
  19. Costa M, Goldberger AL, Peng CK (2002), "Multiscale entropy analysis of complex physiologic time series", Phys Rev Lett, 89 (6): 068102–1–4, Bibcode:2002PhRvL..89f8102C, CiteSeerX 10.1.1.377.7077, doi:10.1103/physrevlett.89.068102, ISSN 0031-9007, PMID 12190613, S2CID 499639
  20. Cancio LC, Batchinsky AI, Baker WL, Necsoiu C, Salinas J, Goldberger AL, Costa MD (2013), "Combat casualties undergoing lifesaving interventions have decreased heart rate complexity at multiple time scales.", J Crit Care, 28 (6): 1093–8, doi:10.1016/j.jcrc.2013.08.022, ISSN 1557-8615, PMC 4018756, PMID 24140167
  21. Costa MD, Schnettler WT, Amorim-Costa C, Bernardes J, Costa A, Goldberger AL, Ayres-de-Campos D (2014), "Complexity-loss in fetal heart rate dynamics during labor as a potential biomarker of acidemia.", Early Hum Dev, 90 (1): 67–71, doi:10.1016/j.earlhumdev.2013.10.002, ISSN 1872-6232, PMC 4077599, PMID 24290526
  22. AAMI Foundation's Laufman-Greatbatch Award
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