Axinelline A

Axinelline A is a COX-2 inhibitor with the molecular formula C12H15NO6 which is produced by the bacterium Streptomyces axinellae.[1][2][3]

Axinelline A
Names
IUPAC name
Ethyl (2S)-2-[(2,3-dihydroxybenzoyl)amino]-3-hydroxypropanoate[1]
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
  • InChI=1S/C12H15NO6/c1-2-19-12(18)8(6-14)13-11(17)7-4-3-5-9(15)10(7)16/h3-5,8,14-16H,2,6H2,1H3,(H,13,17)/t8-/m0/s1
    Key: ZNAULGVROLOSBS-QMMMGPOBSA-N
  • CCOC(=O)[C@H](CO)NC(=O)C1=C(C(=CC=C1)O)O
Properties
C12H15NO6
Molar mass 269.253 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

References
  1. "Axinelline A". pubchem.ncbi.nlm.nih.gov.
  2. Ai, Wen; Lin, Xiu-Ping; Tu, Zhengchao; Tian, Xin-Peng; Lu, Xin; Mangaladoss, Fredimoses; Zhong, Zhi-Long; Liu, Yonghong (18 August 2014). "Axinelline A, a new COX-2 inhibitor from Streptomyces axinellae SCSIO02208". Natural Product Research. 28 (16): 1219–1224. doi:10.1080/14786419.2014.891204.
  3. Andrade, Paula B.; Valentão, Patrícia; Pereira, David M. (30 August 2017). Natural Products Targeting Clinically Relevant Enzymes. John Wiley & Sons. p. 182. ISBN 978-3-527-80591-4.
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