B3GALT5

Beta-1,3-galactosyltransferase 5 is an enzyme that in humans is encoded by the B3GALT5 gene.[5][6]

B3GALT5
Identifiers
AliasesB3GALT5, B3GalT-V, B3GalTx, B3T5, GLCT5, beta-1,3-GalTase 5, beta-3-Gx-T5, beta3Gal-T5, beta-1,3-galactosyltransferase 5
External IDsOMIM: 604066 MGI: 2136878 HomoloGene: 13230 GeneCards: B3GALT5
Orthologs
SpeciesHumanMouse
Entrez

10317

93961

Ensembl

ENSG00000183778

ENSMUSG00000074892

UniProt

Q9Y2C3

Q9JI67

RefSeq (mRNA)

NM_001122993
NM_033149
NM_001358389
NM_001358390

RefSeq (protein)

NP_001116465
NP_149161
NP_001345318
NP_001345319

Location (UCSC)Chr 21: 39.56 – 39.67 MbChr 16: 96.04 – 96.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene encodes the most probable candidate for synthesis of the type 1 Lewis antigens which are frequently found to be elevated in gastrointestinal and pancreatic cancers. The encoded protein is inactive with N-linked glycoproteins and functions in mucin glycosylation. Five transcript variants have been described which differ in the 5' UTR. All transcript variants encode an identical protein.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000183778 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000074892 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Isshiki S, Togayachi A, Kudo T, Nishihara S, Watanabe M, Kubota T, Kitajima M, Shiraishi N, Sasaki K, Andoh T, Narimatsu H (Jun 1999). "Cloning, expression, and characterization of a novel UDP-galactose:beta-N-acetylglucosamine beta1,3-galactosyltransferase (beta3Gal-T5) responsible for synthesis of type 1 chain in colorectal and pancreatic epithelia and tumor cells derived therefrom". J Biol Chem. 274 (18): 12499–507. doi:10.1074/jbc.274.18.12499. PMID 10212226.
  6. "Entrez Gene: B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5".

Further reading


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