BANP

Protein BANP is a protein that can be found in humans, it is encoded by the BANP gene.[5][6][7] It is a member of the human gene family, "BEN-domain containing", which includes eight other genes: BEND2, BEND3, BEND4, BEND5, BEND6, BEND7, NACC1 (BEND8), and NACC2 (BEND9). BANP is a protein coding gene that is located in the Nucleoplasm. Its official name is BTG3 associated with nuclear protein. It plays a role in DNA binding, chromatin regulation, repressor, transcription regulation and the cell cycle process.[8] In recombination BANP protein represses T-cell receptors to control recombination during transcription.[9] As a tumor suppressor BANP negatively regulates p53 transcription in recombination.[10] It can be expressed in various tissues in the body including the testis, spleen, and the placenta.[11]

BANP
Identifiers
AliasesBANP, BEND1, SMAR1, SMARBP1, BTG3 associated nuclear protein
External IDsOMIM: 611564 MGI: 1889023 HomoloGene: 9635 GeneCards: BANP
Orthologs
SpeciesHumanMouse
Entrez

54971

53325

Ensembl

ENSG00000172530

ENSMUSG00000025316

UniProt

Q8N9N5

Q8VBU8

RefSeq (mRNA)

NM_001110100
NM_001285981
NM_001285983
NM_016812

RefSeq (protein)

NP_001103570
NP_001272910
NP_001272912
NP_058092

Location (UCSC)Chr 16: 87.95 – 88.08 MbChr 8: 122.68 – 122.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a protein that binds to matrix attachment regions. The protein functions as a tumor suppressor and cell cycle regulator. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000172530 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025316 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Birot A, Duret L, Bartholin L, Santalucia B, Tigaud I, Magaud J, Rouault J (Aug 2000). "Identification and molecular analysis of BANP". Gene. 253 (2): 189–96. doi:10.1016/S0378-1119(00)00244-4. PMID 10940556.
  6. Chattopadhyay S, Kaul R, Charest A, Housman D, Chen J (Aug 2000). "SMAR1, a novel, alternatively spliced gene product, binds the Scaffold/Matrix-associated region at the T cell receptor beta locus". Genomics. 68 (1): 93–6. doi:10.1006/geno.2000.6279. PMID 10950932.
  7. "Entrez Gene: BANP BTG3 associated nuclear protein".
  8. "National Center for Biotechnology Information". www.ncbi.nlm.nih.gov. Retrieved 2022-05-05.
  9. www.nextprot.org https://www.nextprot.org/entry/NX_Q8N9N5/#!. Retrieved 2022-05-05. {{cite web}}: Missing or empty |title= (help)
  10. "BANP BTG3 associated nuclear protein [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-05-05.
  11. "BANP BTG3 associated nuclear protein [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-05-05.

Further reading


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