BCL2L14

Apoptosis facilitator Bcl-2-like protein 14 is a protein that in humans is encoded by the BCL2L14 gene.[5][6]

BCL2L14
Identifiers
AliasesBCL2L14, BCLG, BCL2 like 14
External IDsOMIM: 606126 MGI: 1914063 HomoloGene: 49840 GeneCards: BCL2L14
Orthologs
SpeciesHumanMouse
Entrez

79370

66813

Ensembl

ENSG00000281449
ENSG00000121380

ENSMUSG00000030200

UniProt

Q9BZR8

Q9CPT0

RefSeq (mRNA)

NM_025778
NM_001355686

RefSeq (protein)

NP_110393
NP_620048
NP_620049
NP_001357197
NP_001357198

NP_080054
NP_001342615

Location (UCSC)Chr 12: 12.05 – 12.21 MbChr 6: 134.37 – 134.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Four alternatively spliced transcript variants, which encode three distinct isoforms, have been reported for this gene.[6]

References

  1. ENSG00000121380 GRCh38: Ensembl release 89: ENSG00000281449, ENSG00000121380 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030200 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Guo B, Godzik A, Reed JC (May 2001). "Bcl-G, a novel pro-apoptotic member of the Bcl-2 family". J Biol Chem. 276 (4): 2780–5. doi:10.1074/jbc.M005889200. PMID 11054413.
  6. "Entrez Gene: BCL2L14 BCL2-like 14 (apoptosis facilitator)".

Further reading


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