Carotenoid-9',10'-cleaving dioxygenase
Carotenoid-9',10'-cleaving dioxygenase (EC 1.13.11.71, BCO2 (gene), beta-carotene 9',10'-monooxygenase (misleading)) is an enzyme with systematic name all-trans-beta-carotene:O2 oxidoreductase (9',10'-cleaving).[1][2] This enzyme catalyses the following chemical reaction
- all-trans-beta-carotene + O2 all-trans-10'-apo-beta-carotenal + beta-ionone
| Carotenoid-9',10'-cleaving dioxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.13.11.71 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Carotenoid-9',10'-cleaving dioxygenase contains Fe2+.
References
- Kiefer C, Hessel S, Lampert JM, Vogt K, Lederer MO, Breithaupt DE, von Lintig J (April 2001). "Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A". The Journal of Biological Chemistry. 276 (17): 14110–6. doi:10.1074/jbc.M011510200. PMID 11278918.
- Lindqvist A, He YG, Andersson S (November 2005). "Cell type-specific expression of beta-carotene 9',10'-monooxygenase in human tissues". The Journal of Histochemistry and Cytochemistry. 53 (11): 1403–12. doi:10.1369/jhc.5A6705.2005. PMID 15983114.
External links
- Carotenoid-9',10'-cleaving+dioxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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