BNC1

Zinc finger protein basonuclin-1 is a protein that in humans is encoded by the BNC1 gene.[5][6]

BNC1
Identifiers
AliasesBNC1, BNC, BSN1, HsT19447, basonuclin 1, POF16
External IDsOMIM: 601930 MGI: 1097164 HomoloGene: 31048 GeneCards: BNC1
Orthologs
SpeciesHumanMouse
Entrez

646

12173

Ensembl

ENSG00000169594

ENSMUSG00000025105

UniProt

Q01954

O35914

RefSeq (mRNA)

NM_001301206
NM_001717

NM_007562

RefSeq (protein)

NP_001288135
NP_001708

NP_031588

Location (UCSC)Chr 15: 83.26 – 83.28 MbChr 7: 81.62 – 81.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. This gene seems to have multiple alternatively spliced transcript variants, but their full-length nature is not known yet. There seems to be evidence of multiple polyadenylation sites for this gene.[6]

BNC1 or Basonuclin 1 does not interact with PICK1. The suggestion that it does is based on the article that proved that PICK1 interacts with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1). Both Basonuclin 1 and brain Na+ channel 1 have the same abbreviation BNC1, but they are not similar proteins and PICK1 interacts with the second protein, not the first one.

References

  1. GRCh38: Ensembl release 89: ENSG00000169594 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025105 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tseng H, Green H (Dec 1992). "Basonuclin: a keratinocyte protein with multiple paired zinc fingers". Proc Natl Acad Sci U S A. 89 (21): 10311–5. Bibcode:1992PNAS...8910311T. doi:10.1073/pnas.89.21.10311. PMC 50328. PMID 1332044.
  6. "Entrez Gene: BNC1 basonuclin 1".

Further reading


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