BNIP3L

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like is a protein that in humans is encoded by the BNIP3L gene.[4][5][6]

BNIP3L
Identifiers
AliasesBNIP3L, BNIP3a, NIX, BCL2/adenovirus E1B 19kDa interacting protein 3-like, BCL2 interacting protein 3 like
External IDsOMIM: 605368 MGI: 3642435 HomoloGene: 3195 GeneCards: BNIP3L
Orthologs
SpeciesHumanMouse
Entrez

665

100043324

Ensembl

ENSG00000104765

n/a

UniProt

O60238
Q6IBV1

n/a

RefSeq (mRNA)

NM_004331
NM_001330491

XM_036157725

RefSeq (protein)

NP_001317420
NP_004322
NP_004322.1

n/a

Location (UCSC)Chr 8: 26.38 – 26.51 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. The protein encoded by this gene is a functional homolog of BNIP3, a proapoptotic protein. This protein may function simultaneously with BNIP3 and may play a role in tumor suppression.[6]

Interactions

BNIP3L has been shown to interact with STEAP3.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000104765 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Matsushima M, Fujiwara T, Takahashi E, Minaguchi T, Eguchi Y, Tsujimoto Y, Suzumori K, Nakamura Y (May 1998). "Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3". Genes Chromosomes Cancer. 21 (3): 230–5. doi:10.1002/(SICI)1098-2264(199803)21:3<230::AID-GCC7>3.0.CO;2-0. PMID 9523198. S2CID 45529298.
  5. Yasuda M, Han JW, Dionne CA, Boyd JM, Chinnadurai G (Feb 1999). "BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3". Cancer Res. 59 (3): 533–7. PMID 9973195.
  6. "Entrez Gene: BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like".
  7. Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A (Mar 2003). "The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2284–9. Bibcode:2003PNAS..100.2284P. doi:10.1073/pnas.0530298100. PMC 151332. PMID 12606722.

Further reading


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