BRD8

Bromodomain-containing protein 8 is a protein that in humans is encoded by the BRD8 gene.[5][6][7]

BRD8
Identifiers
AliasesBRD8, SMAP, SMAP2, p120, bromodomain containing 8
External IDsOMIM: 602848 MGI: 1925906 HomoloGene: 41790 GeneCards: BRD8
Orthologs
SpeciesHumanMouse
Entrez

10902

78656

Ensembl

ENSG00000112983

ENSMUSG00000003778

UniProt

Q9H0E9

Q8R3B7

RefSeq (mRNA)

NM_001289606
NM_001289607
NM_030147
NM_001361136

RefSeq (protein)

NP_001276535
NP_001276536
NP_084423
NP_001348065

Location (UCSC)Chr 5: 138.14 – 138.18 MbChr 18: 34.73 – 34.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode distinct isoforms have been identified.[7]

Interactions

BRD8 has been shown to interact with Thyroid hormone receptor beta[6] and Retinoid X receptor alpha.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000112983 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000003778 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nielsen MS, Petersen CM, Gliemann J, Madsen P (April 1996). "Cloning and sequencing of a human cDNA encoding a putative transcription factor containing a bromodomain". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1306 (1): 14–6. doi:10.1016/0167-4781(95)00239-1. PMID 8611617.
  6. Monden T, Wondisford FE, Hollenberg AN (November 1997). "Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein". The Journal of Biological Chemistry. 272 (47): 29834–41. doi:10.1074/jbc.272.47.29834. PMID 9368056.
  7. "Entrez Gene: BRD8 bromodomain containing 8".
  8. Monden T, Kishi M, Hosoya T, Satoh T, Wondisford FE, Hollenberg AN, Yamada M, Mori M (October 1999). "p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers". Molecular Endocrinology. 13 (10): 1695–703. doi:10.1210/mend.13.10.0353. PMID 10517671. S2CID 25098867.

Further reading


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