CUGBP Elav-like family member 4
CUGBP Elav-like family member 4 (CELF4) also known as bruno-like protein 4 (BRUNOL4) is a protein that in humans is encoded by the CELF4 gene.[4][5]
Function
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Several transcript variants encoding different isoforms have been found for this gene, but their full-length nature has not been determined yet.[5]
References
- GRCm38: Ensembl release 89: ENSMUSG00000024268 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Good PJ, Chen Q, Warner SJ, Herring DC (Oct 2000). "A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator". J Biol Chem. 275 (37): 28583–92. doi:10.1074/jbc.M003083200. PMID 10893231.
- "Entrez Gene: BRUNOL4 bruno-like 4, RNA binding protein (Drosophila)".
External links
- Human CELF4 genome location and CELF4 gene details page in the UCSC Genome Browser.
Further reading
- Szafranski K, Schindler S, Taudien S, et al. (2008). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biol. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.
- Han J, Cooper TA (2005). "Identification of CELF splicing activation and repression domains in vivo". Nucleic Acids Res. 33 (9): 2769–80. doi:10.1093/nar/gki561. PMC 1126903. PMID 15894795.
- Singh G, Charlet-B N, Han J, Cooper TA (2004). "ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo". Nucleic Acids Res. 32 (3): 1232–41. doi:10.1093/nar/gkh275. PMC 373409. PMID 14973222.
- Tchernev VT, Mansfield TA, Giot L, et al. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Mol. Med. 8 (1): 56–64. doi:10.1007/bf03402003. PMC 2039936. PMID 11984006.
- Ladd AN, Charlet N, Cooper TA (2001). "The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing". Mol. Cell. Biol. 21 (4): 1285–96. doi:10.1128/MCB.21.4.1285-1296.2001. PMC 99581. PMID 11158314.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
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