BTAF1

TATA-binding protein-associated factor 172 is a protein that in humans is encoded by the BTAF1 gene.[5][6][7]

BTAF1
Identifiers
AliasesBTAF1, MOT1, TAF(II)170, TAF172, TAFII170, B-TFIID TATA-box binding protein associated factor 1
External IDsOMIM: 605191 MGI: 2147538 HomoloGene: 31978 GeneCards: BTAF1
Orthologs
SpeciesHumanMouse
Entrez

9044

107182

Ensembl

ENSG00000095564

ENSMUSG00000040565

UniProt

O14981
Q2M1V9

E9QAE3

RefSeq (mRNA)

NM_003972

NM_001080706

RefSeq (protein)

NP_003963
NP_003963.1

NP_001074175

Location (UCSC)Chr 10: 91.92 – 92.03 MbChr 19: 36.9 – 36.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Initiation of transcription by RNA polymerase II requires the assistance of TATA box-binding protein (TBP; MIM 600075) and TBP-associated factors, or TAFs (e.g., TAF2B; MIM 604912), in 2 distinct complexes, TFIID and B-TFIID. The TFIID complex is composed of TBP and more than 8 TAFs. However, the majority of TBP is present in the B-TFIID complex, which is composed of TBP and TAFII170, also called TAF172, and has DNA-dependent ATPase activity.[supplied by OMIM][7]

Interactions

BTAF1 has been shown to interact with TATA binding protein.[6][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000095564 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000040565 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. van der Knaap JA, Borst JW, van der Vliet PC, Gentz R, Timmers HT (Dec 1997). "Cloning of the cDNA for the TATA-binding protein-associated factorII170 subunit of transcription factor B-TFIID reveals homology to global transcription regulators in yeast and Drosophila". Proc Natl Acad Sci U S A. 94 (22): 11827–32. Bibcode:1997PNAS...9411827V. doi:10.1073/pnas.94.22.11827. PMC 23617. PMID 9342322.
  6. Chicca JJ, Auble DT, Pugh BF (Mar 1998). "Cloning and Biochemical Characterization of TAF-172, a Human Homolog of Yeast Mot1". Mol Cell Biol. 18 (3): 1701–10. doi:10.1128/MCB.18.3.1701. PMC 108885. PMID 9488487.
  7. "Entrez Gene: BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)".
  8. Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. Bibcode:1997PNAS...94.5605S. doi:10.1073/pnas.94.11.5605. PMC 20825. PMID 9159119.

Further reading


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