BTBD2

BTB/POZ domain-containing protein 2 is a protein that in humans is encoded by the BTBD2 gene.[5][6]

BTBD2
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesBTBD2, BTB domain containing 2
External IDsOMIM: 608531 MGI: 1933831 HomoloGene: 32365 GeneCards: BTBD2
Orthologs
SpeciesHumanMouse
Entrez

55643

208198

Ensembl

ENSG00000133243

ENSMUSG00000003344

UniProt

Q9BX70

n/a

RefSeq (mRNA)

NM_017797

NM_145361
NM_001379084

RefSeq (protein)

NP_060267

n/a

Location (UCSC)Chr 19: 1.99 – 2.03 MbChr 10: 80.48 – 80.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies.[6]

Interactions

BTBD2 has been shown to interact with TOP1.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000133243 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000003344 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Carim-Todd L, Sumoy L, Andreu N, Estivill X, Escarceller M (Jan 2001). "Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24". Gene. 262 (1–2): 275–81. doi:10.1016/S0378-1119(00)00513-8. PMID 11179693.
  6. "Entrez Gene: BTBD2 BTB (POZ) domain containing 2".
  7. Xu L, Yang L, Hashimoto K, Anderson M, Kohlhagen G, Pommier Y, D'Arpa P (2002). "Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I". BMC Genomics. 3: 1. doi:10.1186/1471-2164-3-1. PMC 64781. PMID 11818025.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.