Bag-1 internal ribosome entry site (IRES)
The bag-1 internal ribosome entry site (IRES) is a cis-acting element located in the 5 ' untranslated region of the BAG-1 protein mRNA. Its effects apoptosis through IRES mediated translation of the BAG-1 protein.[1]
| Bag-1 internal ribosome entry site (IRES) | |
|---|---|
 Predicted secondary structure and sequence conservation of IRES_Bag1 | |
| Identifiers | |
| Symbol | IRES_Bag1 |
| Alt. Symbols | Bag1_IRES |
| Rfam | RF00222 |
| Other data | |
| RNA type | Cis-reg; IRES |
| Domain(s) | Eukaryota |
| GO | GO:0043022 |
| SO | SO:0000243 |
| PDB structures | PDBe |
When expressed, the BAG-1 protein is known to enhance the anti-apoptotic properties of the Bcl-2 protein. Although bag-1 translation usually occurs via a cap-dependent mechanism it has been found to contain an IRES in its 5' UTR. Translation via the IRES has been found to be common following heat shock when cap-dependent scanning is compromised.[1]
References
- Coldwell MJ, deSchoolmeester ML, Fraser GA, Pickering BM, Packham G, Willis AE (2001). "The p36 isoform of BAG-1 is translated by internal ribosome entry following heat shock". Oncogene. 20 (30): 4095–4100. doi:10.1038/sj.onc.1204547. PMID 11494137.
External links
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