Barakol

Barakol
Clinical data
ATC code	none;
Identifiers
	IUPAC name 2,5-Dimethyl-3aH-pyrano[2,3,4-de]-1-benzopyran-3a,8-diol;
CAS Number	24506-68-1 ;
PubChem CID	3080731;
ChemSpider	2338470 ;
UNII	EZC4ABS2MU;
CompTox Dashboard (EPA)	DTXSID30947398 ;
Chemical and physical data
Formula	C13H12O4
Molar mass	232.235 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC2=Cc3cc(O)cc(c13)OC(C)=CC1(O)O2;
	InChI InChI=1S/C13H12O4/c1-7-3-9-4-10(14)5-11-12(9)13(15,17-7)6-8(2)16-11/h3-6,14-15H,1-2H3 ; Key:LVPNMZHEDIKUFK-UHFFFAOYSA-N ;
	(what is this?) (verify)

Barakol is a compound found in the plant Senna siamea,[1] which is used in traditional herbal medicine. It has sedative and anxiolytic effects.[2][3] There are contradictory pharmacological research findings concerning the toxicity of Cassia siamea and the active ingredient Barakol. One pharmacological study has shown an hepatoxic effect of Barakol [4] while another study did not show any toxic effect at a daily dosage intake.[5] Further research is needed to verify whether there are toxic effects of Barakol or not.

References

Padumanonda T, Gritsanapan W (March 2006). "Barakol contents in fresh and cooked Senna siamea leaves". The Southeast Asian Journal of Tropical Medicine and Public Health. 37 (2): 388–93. PMID 17125004.
Thongsaard W, Pongsakorn S, Sudsuang R, Bennett GW, Kendall DA, Marsden CA (January 1997). "Barakol, a natural anxiolytic, inhibits striatal dopamine release but off uptake in vitro". European Journal of Pharmacology. 319 (2–3): 157–64. doi:10.1016/S0014-2999(96)00850-3. PMID 9042586.
Sukma M, Chaichantipyuth C, Murakami Y, Tohda M, Matsumoto K, Watanabe H (November 2002). "CNS inhibitory effects of barakol, a constituent of Cassia siamia Lamk". Journal of Ethnopharmacology. 83 (1–2): 87–94. doi:10.1016/S0378-8741(02)00206-4. PMID 12413711.
Hongsirinirachorn M, Threeprasertsuk S, Chutaputti A (June 2003). "Acute hepatitis associated with Barakol". Journal of the Medical Association of Thailand = Chotmaihet Thangphaet. 86 (Suppl 2): S484-9. PMID 12930029.
Wahjoedi B, Pudjiastuti P, Nuratmi B, Sundari D, Chozin A (December 1999). "Toksisitas Subkronik Ekstrak Etanol Daun Johar (Cassia Siamea Lamk.) Pada Tikus Putih [The subchronic toxicity study of the ethanolic extract of Cassia siamea lamk leaf (daun johar) on albino rats]". Bulletin of Health Research = Buletin Penelitian Kesehatan = National Institute of Health Research and Development - Ministry of Health of Republic of Indonesia. 27 Suppl. 3 & 4: S325–332.

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[pmid17125004-1] Padumanonda T, Gritsanapan W (March 2006). "Barakol contents in fresh and cooked Senna siamea leaves". The Southeast Asian Journal of Tropical Medicine and Public Health. 37 (2): 388–93. PMID 17125004.

[pmid9042586-2] Thongsaard W, Pongsakorn S, Sudsuang R, Bennett GW, Kendall DA, Marsden CA (January 1997). "Barakol, a natural anxiolytic, inhibits striatal dopamine release but off uptake in vitro". European Journal of Pharmacology. 319 (2–3): 157–64. doi:10.1016/S0014-2999(96)00850-3. PMID 9042586.

[pmid12413711-3] Sukma M, Chaichantipyuth C, Murakami Y, Tohda M, Matsumoto K, Watanabe H (November 2002). "CNS inhibitory effects of barakol, a constituent of Cassia siamia Lamk". Journal of Ethnopharmacology. 83 (1–2): 87–94. doi:10.1016/S0378-8741(02)00206-4. PMID 12413711.

[pmid12930029-4] Hongsirinirachorn M, Threeprasertsuk S, Chutaputti A (June 2003). "Acute hepatitis associated with Barakol". Journal of the Medical Association of Thailand = Chotmaihet Thangphaet. 86 (Suppl 2): S484-9. PMID 12930029.

[5] Wahjoedi B, Pudjiastuti P, Nuratmi B, Sundari D, Chozin A (December 1999). "Toksisitas Subkronik Ekstrak Etanol Daun Johar (Cassia Siamea Lamk.) Pada Tikus Putih [The subchronic toxicity study of the ethanolic extract of Cassia siamea lamk leaf (daun johar) on albino rats]". Bulletin of Health Research = Buletin Penelitian Kesehatan = National Institute of Health Research and Development - Ministry of Health of Republic of Indonesia. 27 Suppl. 3 & 4: S325–332.