Bicoid 3′-UTR regulatory element

The bicoid 3′-UTR regulatory element is an mRNA regulatory element that controls the gene expression of the bicoid protein in fruitfly Drosophila melanogaster.

Bicoid 3′-UTR regulatory element
Stem-loop structure of the bicoid 3′-UTR regulatory element
Identifiers
Symbolbcd
RfamRF00551
Other data
RNA typeCis-reg
Domain(s)Insecta
PDB structuresPDBe

The structured RNA element consists of four domains (denoted as II, III, IV and V) in the 3′UTR of the mRNA. It is essential for the correct transport and localisation of bicoid mRNA during oocyte and embryo differentiation, which has been studied most thoroughly in the development of Drosophila melanogaster (fruitfly) larvae.[1][2][3][4]

References
  1. Macdonald PM, Struhl G (December 1988). "cis-acting sequences responsible for anterior localization of bicoid mRNA in Drosophila embryos". Nature. 336 (6199): 595–598. Bibcode:1988Natur.336..595M. doi:10.1038/336595a0. PMID 3143913. S2CID 4353831.
  2. MacDonald PM (September 1990). "bicoid mRNA localization signal: phylogenetic conservation of function and RNA secondary structure". Development. 110 (1): 161–171. doi:10.1242/dev.110.1.161. PMID 2081457.
  3. Seeger MA, Kaufman TC (September 1990). "Molecular analysis of the bicoid gene from Drosophila pseudoobscura: identification of conserved domains within coding and noncoding regions of the bicoid mRNA". The EMBO Journal. 9 (9): 2977–2987. doi:10.1002/j.1460-2075.1990.tb07490.x. PMC 552015. PMID 1975239.
  4. Brunel C, Ehresmann C (February 2004). "Secondary structure of the 3′ UTR of bicoid mRNA". Biochimie. 86 (2): 91–104. doi:10.1016/j.biochi.2004.01.002. PMID 15016447.
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