Bifidus factor

A bifidus factor (bifidogenic factor) is a compound that specifically enhances the growth of bifidobacteria in either a product or in the intestines of humans and/or animals. Several products have been marketed as bifidogenic factors, such as several prebiotics and methyl-N-acetyl D-glucosamine in human milk.[1][2][3]

Background

Originally, fructose-based carbohydrates inulin and fructooligosaccharides, showed a strong selective stimulation of bifidobacteria so a ‘prebiotic effect’ was considered the same as a ‘bifidogenic effect.[4]

Breast milk

Human breast milk contains unique and highly diverse human milk oligosaccharides. These oligosaccharides are considered to be a "Bifidus Factor" because they form highly desired intestinal bacteria; it is for this reason that baby formula contains added oligosaccharides in order to help build a child's immune system. Studies showed that infants, who were bottled fed, lacked intestinal colonization of bifidobacteria. This lack of bacteria made the babies susceptible to other infectious bacteria and ailments. The infants who were breast fed had higher concentration of the bacteria and their vulnerability too infections was significantly lower. Breast milk had high amounts of oligosaccharides. As, a result, oligosaccharides were added to milk formula. This method worked and the colonization of bifidobacteria leveled. This suggested that the oligosaccharides found in human milk were candidates for the bifidus factor.

Composition and function

The bifidus factor might be lacto-N-biose I [LNB], which is a derivative of mucin sugars. However, the exact structure and mechanism behind the bifidus factor remains unknown.[5]

The bacteria would break down lactic acid and acetic acid. The environment of the intestine would become acidic, preventing the growth of any harmful pathogens. The function of LBN is unknown and it is possible that oligosaccharides with terminals of Galβ1-3GlcNAc are the bifidus factors.[6]

Bifidobacteria might suppress infections in infants and children.

References

"Bifidogenic". Encyclopedia.com. Retrieved 18 December 2021.
Moro, G; Minoli, I; Mosca, M; Fanaro, S; Jelinek, J; Stahl, B; Boehm, G (2002). "Dosage-Related Bifidogenic Effects of Galacto- and Fructooligosaccharides in Formula-Fed Term Infants". Journal of Pediatric Gastroenterology and Nutrition. 34 (3): 291–5. doi:10.1097/00005176-200203000-00014. PMID 11964956. S2CID 9704332.
Fanaro, Silvia; Marten, Berit; Bagna, Rossana; Vigi, Vittorio; Fabris, Claudio; Peña-Quintana, Luis; Argüelles, Federico; Scholz-Ahrens, Katharina E; et al. (2009). "Galacto-oligosaccharides Are Bifidogenic and Safe at Weaning: A Double-blind Randomized Multicenter Study". Journal of Pediatric Gastroenterology and Nutrition. 48 (1): 82–8. doi:10.1097/MPG.0b013e31817b6dd2. PMID 19172129. S2CID 31875747.
Schwiertz, Andreas, ed. (2016). Microbiota of the Human Body: Implications in Health and Disease. Advances in Experimental Medicine and Biology. Vol. 902. Cham: Springer International Publishing. p. 120. doi:10.1007/978-3-319-31248-4. ISBN 978-3-319-31246-0. S2CID 28970333.
Kitaoka, Motomitsu; Tian, Jiesheng; Nishimoto, Mamoru (June 2005). "Novel Putative Galactose Operon Involving Lacto-N-Biose Phosphorylase in Bifidobacterium longum". Applied and Environmental Microbiology. 71 (6): 3158–3162. Bibcode:2005ApEnM..71.3158K. doi:10.1128/AEM.71.6.3158-3162.2005. ISSN 0099-2240. PMC 1151866. PMID 15933016.
KOBATA, Akira (2010-07-21). "Structures and application of oligosaccharides in human milk". Proceedings of the Japan Academy. Series B, Physical and Biological Sciences. 86 (7): 731–747. Bibcode:2010PJAB...86..731K. doi:10.2183/pjab.86.731. ISSN 0386-2208. PMC 3066539. PMID 20689231.

Other sources

O'Callaghan, Amy; van Sinderen, Douwe (2016). Bifidobacteria and Their Role as Members of the Human Gut Microbiota. Frontiers in Microbiology, 7, doi:10.3389/fmicb.2016.00925
Paul György; Robert F. Norris; Catharine S. Rose (1954). Bifidus factor. I. A variant of Lactobacillus bifidus requiring a special growth factor, 48 (1), 193–201. doi:10.1016/0003-9861(54)90323-9

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[1] "Bifidogenic". Encyclopedia.com. Retrieved 18 December 2021.

[2] Moro, G; Minoli, I; Mosca, M; Fanaro, S; Jelinek, J; Stahl, B; Boehm, G (2002). "Dosage-Related Bifidogenic Effects of Galacto- and Fructooligosaccharides in Formula-Fed Term Infants". Journal of Pediatric Gastroenterology and Nutrition. 34 (3): 291–5. doi:10.1097/00005176-200203000-00014. PMID 11964956. S2CID 9704332.

[3] Fanaro, Silvia; Marten, Berit; Bagna, Rossana; Vigi, Vittorio; Fabris, Claudio; Peña-Quintana, Luis; Argüelles, Federico; Scholz-Ahrens, Katharina E; et al. (2009). "Galacto-oligosaccharides Are Bifidogenic and Safe at Weaning: A Double-blind Randomized Multicenter Study". Journal of Pediatric Gastroenterology and Nutrition. 48 (1): 82–8. doi:10.1097/MPG.0b013e31817b6dd2. PMID 19172129. S2CID 31875747.

[4] Schwiertz, Andreas, ed. (2016). Microbiota of the Human Body: Implications in Health and Disease. Advances in Experimental Medicine and Biology. Vol. 902. Cham: Springer International Publishing. p. 120. doi:10.1007/978-3-319-31248-4. ISBN 978-3-319-31246-0. S2CID 28970333.

[5] Kitaoka, Motomitsu; Tian, Jiesheng; Nishimoto, Mamoru (June 2005). "Novel Putative Galactose Operon Involving Lacto-N-Biose Phosphorylase in Bifidobacterium longum". Applied and Environmental Microbiology. 71 (6): 3158–3162. Bibcode:2005ApEnM..71.3158K. doi:10.1128/AEM.71.6.3158-3162.2005. ISSN 0099-2240. PMC 1151866. PMID 15933016.

[6] KOBATA, Akira (2010-07-21). "Structures and application of oligosaccharides in human milk". Proceedings of the Japan Academy. Series B, Physical and Biological Sciences. 86 (7): 731–747. Bibcode:2010PJAB...86..731K. doi:10.2183/pjab.86.731. ISSN 0386-2208. PMC 3066539. PMID 20689231.