Bile salt sulfotransferase
Bile salt sulfotransferase also known as hydroxysteroid sulfotransferase (HST) or sulfotransferase 2A1 (ST2A1) is an enzyme that in humans is encoded by the SULT2A1 gene.[5][6][7]
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| Aliases | SULT2A1, DHEA-ST, DHEAS, HST, ST2, ST2A1, ST2A3, STD, hSTa, sulfotransferase family 2A member 1, DHEA-ST8, SULT2A3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 125263 MGI: 3645854 HomoloGene: 37741 GeneCards: SULT2A1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene is primarily expressed in liver and adrenal tissues where the encoded protein sulfonates steroids and bile acids.[5]
References
- GRCh38: Ensembl release 89: ENSG00000105398 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000074377 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1".
- Otterness DM, Wieben ED, Wood TC, Watson WG, Madden BJ, McCormick DJ, Weinshilboum RM (May 1992). "Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA". Mol. Pharmacol. 41 (5): 865–72. PMID 1588921.
- Otterness DM, Mohrenweiser HW, Brandriff BF, Weinshilboum RM (1995). "Dehydroepiandrosterone sulfotransferase gene (STD): localization to human chromosome band 19q13.3". Cytogenet. Cell Genet. 70 (1–2): 45–7. doi:10.1159/000133988. PMID 7736787.
Further reading
- Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes". FASEB J. 11 (1): 3–14. doi:10.1096/fasebj.11.1.9034160. PMID 9034160. S2CID 12532583.
- Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology". Toxicol. Lett. 112–113: 341–8. doi:10.1016/S0378-4274(99)00214-3. PMID 10720750.
- Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects". Mutat. Res. 482 (1–2): 27–40. doi:10.1016/S0027-5107(01)00207-X. PMID 11535246.
- Kong AN, Yang L, Ma M, et al. (1992). "Molecular cloning of the alcohol/hydroxysteroid form (hSTa) of sulfotransferase from human liver". Biochem. Biophys. Res. Commun. 187 (1): 448–54. doi:10.1016/S0006-291X(05)81514-1. PMID 1520333.
- Comer KA, Falany CN (1992). "Immunological characterization of dehydroepiandrosterone sulfotransferase from human liver and adrenal". Mol. Pharmacol. 41 (4): 645–51. PMID 1569919.
- Otterness DM, Wieben ED, Wood TC, et al. (1992). "Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA". Mol. Pharmacol. 41 (5): 865–72. PMID 1588921.
- Radominska A, Comer KA, Zimniak P, et al. (1991). "Human liver steroid sulphotransferase sulphates bile acids". Biochem. J. 272 (3): 597–604. doi:10.1042/bj2720597. PMC 1149750. PMID 2268288.
- Forbes KJ, Hagen M, Glatt H, et al. (1995). "Human fetal adrenal hydroxysteroid sulphotransferase: cDNA cloning, stable expression in V79 cells and functional characterisation of the expressed enzyme". Mol. Cell. Endocrinol. 112 (1): 53–60. doi:10.1016/0303-7207(95)03585-U. PMID 7589785. S2CID 39327051.
- Luu-The V, Dufort I, Paquet N, et al. (1995). "Structural characterization and expression of the human dehydroepiandrosterone sulfotransferase gene". DNA Cell Biol. 14 (6): 511–8. doi:10.1089/dna.1995.14.511. PMID 7598806.
- Comer KA, Falany JL, Falany CN (1993). "Cloning and expression of human liver dehydroepiandrosterone sulphotransferase". Biochem. J. 289 (1): 233–40. doi:10.1042/bj2890233. PMC 1132155. PMID 7678732.
- Otterness DM, Her C, Aksoy S, et al. (1995). "Human dehydroepiandrosterone sulfotransferase gene: molecular cloning and structural characterization". DNA Cell Biol. 14 (4): 331–41. doi:10.1089/dna.1995.14.331. PMID 7710689.
- Otterness DM, Mohrenweiser HW, Brandriff BF, Weinshilboum RM (1995). "Dehydroepiandrosterone sulfotransferase gene (STD): localization to human chromosome band 19q13.3". Cytogenet. Cell Genet. 70 (1–2): 45–7. doi:10.1159/000133988. PMID 7736787.
- Falany CN, Wheeler J, Oh TS, Falany JL (1994). "Steroid sulfation by expressed human cytosolic sulfotransferases". J. Steroid Biochem. Mol. Biol. 48 (4): 369–75. doi:10.1016/0960-0760(94)90077-9. PMID 8142314. S2CID 37646598.
- Barker EV, Hume R, Hallas A, Coughtrie WH (1994). "Dehydroepiandrosterone sulfotransferase in the developing human fetus: quantitative biochemical and immunological characterization of the hepatic, renal, and adrenal enzymes". Endocrinology. 134 (2): 982–9. doi:10.1210/endo.134.2.8299591. PMID 8299591.
- Durocher F, Morissette J, Dufort I, et al. (1996). "Genetic linkage mapping of the dehydroepiandrosterone sulfotransferase (STD) gene on the chromosome 19q13.3 region". Genomics. 29 (3): 781–3. doi:10.1006/geno.1995.9935. PMID 8575776.
- Rubin GL, Harrold AJ, Mills JA, et al. (1999). "Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy". Mol. Hum. Reprod. 5 (11): 995–1002. doi:10.1093/molehr/5.11.995. PMID 10541560.
- Tashiro A, Sasano H, Nishikawa T, et al. (2000). "Expression and activity of dehydroepiandrosterone sulfotransferase in human gastric mucosa". J. Steroid Biochem. Mol. Biol. 72 (3–4): 149–54. doi:10.1016/S0960-0760(00)00020-0. PMID 10775806. S2CID 44681209.
- Pedersen LC, Petrotchenko EV, Negishi M (2000). "Crystal structure of SULT2A3, human hydroxysteroid sulfotransferase". FEBS Lett. 475 (1): 61–4. doi:10.1016/S0014-5793(00)01479-4. PMID 10854859. S2CID 38252369.
External links
- alcohol+sulfotransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human SULT2A1 genome location and SULT2A1 gene details page in the UCSC Genome Browser.
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