Bomanin

The Bomanin gene family encodes a group of immune peptides that are essential for Drosophila fruit fly defence against infection by many pathogens.[1][2]

Bomanin
The fruit fly, Drosophila melanogaster
Identifiers
OrganismDrosophila melanogaster
SymbolBom
UniProtP82706
Search for
StructuresSwiss-model
DomainsInterPro

The gene family is named in honour of Hans G. Boman, for his contributions to innate immunity and the discovery of antimicrobial peptides.[1] While Bomanins are essential for survival after infection by many kinds of Gram-positive bacteria and pathogenic fungi, the reason they are key to defence may be because Bomanins promote resilience to pathogen toxins, and not because they directly suppress pathogens.[3] However fly hemolymph (blood) loses its fungicidal activity in the absence of Bomanins, suggesting these peptides are also somehow needed to turn the hemolymph into an antimicrobial environment.[4]

See also

References
  1. Clemmons AW, Lindsay SA, Wasserman SA (April 2015). Silverman N (ed.). "An effector Peptide family required for Drosophila toll-mediated immunity". PLOS Pathogens. 11 (4): e1004876. doi:10.1371/journal.ppat.1004876. PMC 4411088. PMID 25915418.
  2. Hanson MA, Dostálová A, Ceroni C, Poidevin M, Kondo S, Lemaitre B (February 2019). "Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach". eLife. 8: e44341. doi:10.7554/eLife.44341. PMC 6398976. PMID 30803481.
  3. Xu R, Lou Y, Tidu A, Bulet P, Heinekamp T, Martin F, et al. (January 2023). "The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins". EMBO Reports. 24 (1): e56036. doi:10.15252/embr.202256036. PMC 9827548. PMID 36322050.
  4. Lindsay SA, Lin SJ, Wasserman SA (2018). "Short-Form Bomanins Mediate Humoral Immunity in Drosophila". Journal of Innate Immunity. 10 (4): 306–314. doi:10.1159/000489831. PMC 6158068. PMID 29920489.
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