CDCA8

Borealin is a protein that in humans is encoded by the CDCA8 gene.[5][6][7]

CDCA8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCDCA8, BOR, BOREALIN, DasraB, MESRGP, cell division cycle associated 8
External IDsOMIM: 609977 MGI: 1196274 HomoloGene: 23075 GeneCards: CDCA8
Orthologs
SpeciesHumanMouse
Entrez

55143

52276

Ensembl

ENSG00000134690

ENSMUSG00000028873

UniProt

Q53HL2

Q8BHX3

RefSeq (mRNA)

NM_018101
NM_001256875

NM_026560

RefSeq (protein)

NP_001243804
NP_060571

NP_080836

Location (UCSC)Chr 1: 37.69 – 37.71 MbChr 4: 124.81 – 124.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

CDCA8 is a component of a chromosomal passenger complex required for stability of the bipolar mitotic spindle.[7][8]

Interactions

CDCA8 has been shown to interact with INCENP,[8] Survivin[6][8] and Aurora B kinase.[6][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000134690 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028873 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Walker MG (May 2001). "Drug target discovery by gene expression analysis: cell cycle genes". Current Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
  6. Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H (Jul 2004). "The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly". Cell. 118 (2): 187–202. doi:10.1016/j.cell.2004.06.026. PMID 15260989.
  7. "Entrez Gene: CDCA8 cell division cycle associated 8".
  8. Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (Jul 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". The Journal of Cell Biology. 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC 2172304. PMID 15249581.

Further reading


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