Bridging integrator 3

Bridging integrator 3 is a protein that in humans is encoded by the BIN3 gene.[5][6]

BIN3
Identifiers
AliasesBIN3, bridging integrator 3
External IDsOMIM: 606396 MGI: 1929883 HomoloGene: 5472 GeneCards: BIN3
Orthologs
SpeciesHumanMouse
Entrez

55909

57784

Ensembl

ENSG00000147439

ENSMUSG00000022089

UniProt

Q9NQY0

Q9JI08

RefSeq (mRNA)

NM_018688
NM_001363046

NM_021328
NM_001360404

RefSeq (protein)

NP_061158
NP_001349975

NP_067303
NP_001347333

Location (UCSC)Chr 8: 22.62 – 22.67 MbChr 14: 70.34 – 70.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The product of this gene is a member of the BAR domain protein family. The encoded protein is composed solely of a BAR domain which is predicted to form coiled coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000147439 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022089 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ren G, Vajjhala P, Lee JS, Winsor B, Munn AL (Mar 2006). "The BAR domain proteins: molding membranes in fission, fusion, and phagy". Microbiol Mol Biol Rev. 70 (1): 37–120. doi:10.1128/MMBR.70.1.37-120.2006. PMC 1393252. PMID 16524918.
  6. "Entrez Gene: BIN3 bridging integrator 3".

Further reading


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