Bronidox

Bronidox
Names
	Preferred IUPAC name 5-Bromo-5-nitro-1,3-dioxane
	Other names 5-Bromo-5-nitro-m-dioxane
Identifiers
CAS Number	30007-47-7 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL3185787;
ChemSpider	1741 ;
ECHA InfoCard	100.045.441
EC Number	250-001-7;
PubChem CID	1807;
UNII	U184I9QBNM ;
CompTox Dashboard (EPA)	DTXSID1044560 ;
	InChI InChI=1S/C4H6BrNO4/c5-4(6(7)8)1-9-3-10-2-4/h1-3H2 Key: XVBRCOKDZVQYAY-UHFFFAOYSA-N ; InChI=1/C4H6BrNO4/c5-4(6(7)8)1-9-3-10-2-4/h1-3H2 Key: XVBRCOKDZVQYAY-UHFFFAOYAG;
	SMILES O=[N+]([O-])C1(Br)COCOC1;
Properties
Chemical formula	C4H6BrNO4
Molar mass	211.999 g·mol−1
Appearance	White crystalline powder
Melting point	60 °C (140 °F; 333 K)[1]; 58.5−62 °C[2]
Solubility in water	insoluble
Hazards
	GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H302, H314, H315, H317, H410
Precautionary statements	P260, P261, P264, P270, P272, P273, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P330, P332+P313, P333+P313, P362, P363, P391, P405, P501
	Lethal dose or concentration (LD, LC):
LD50 (median dose)	590 mg/kg (mouse, oral); 455 mg/kg (rat, oral); 31 mg/kg (rat, ipr.); 2500 µg (mouse, skin); 2500 µg (rat, skin)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Bronidox, or 5-bromo-5-nitro-1,3-dioxane, is an antimicrobial chemical compound.

Bronidox causes inhibition of enzyme activity in bacteria.[3]

Bronidox is corrosive to metals.[4]

Uses

Bactericide
Fungicide, effective against yeast and other fungi
It is used in immunology for preserving antibodies and antisera in 0.1 - 0.5% concentration. It is used as preservative to avoid use of sodium azide.
Stabilizer
Surfactant
Used in cosmetics since the mid-1970s as preservative for shampoos, foam bath, etc. Maximum concentration is 0.1%.
Some users do not recommend use in preparations destined for in vivo or tissue culture work[5]

5-BROMO-5-NITRO-1,3-DIOXANE Archived March 3, 2016, at the Wayback Machine, chemicalland21.com
"Bronidox, Product Information Sheet" (PDF). Archived from the original (PDF) on September 29, 2007. Retrieved March 19, 2006.
Ghannoum M, Thomson M, Bowman W, Al-Khalil S (1986). "Mode of action of the antimicrobial compound 5-bromo-5-nitro-1,3-dioxane (bronidox)". Folia Microbiol. (Praha). 31 (1): 19–31. doi:10.1007/BF02928676. PMID 3082729. S2CID 23920602.
http://www.products.cognis.com/COGNIS/prodleaf.nsf/(SBU_Catalog)/FFAD30C61B67EFEB41256B4100427DD1/$File/BRONIDOX_r_L_5_E.pdf
Archived December 21, 2004, at the Wayback Machine

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