Bruno H. Zimm

Bruno Hasbrouck Zimm (October 31, 1920 – November 26, 2005) was an American chemist. He was a professor of chemistry and biochemistry from University of California, San Diego, and a leading polymer chemist and DNA researcher.[3][4]

For the artist, see Bruno Zimm (artist).
Bruno H. Zimm
Born(1920-10-31)October 31, 1920
Woodstock, New York, United States
DiedNovember 26, 2005(2005-11-26) (aged 85)
La Jolla, California, United States
NationalityAmerican
Alma materColumbia University
Known forPolymer chemist & DNA researcher
AwardsFellow of the APS (1953)[1]
Member of the NAS (1958)[2]
NAS Award in Chemical Sciences (1981)
Scientific career
FieldsChemistry
Doctoral advisorJoseph E. Mayer
Doctoral studentsDonald Crothers
Ken A. Dill

Early life

Zimm was born an only child in 1920 in Woodstock, New York.[5] His father was the sculptor Bruno Louis Zimm, and his mother a writer. Zimm graduated from Kent School in Kent, Connecticut in 1938.[6] After obtaining his Ph.D. in physical chemistry under the tutelage of Joe Mayer at Columbia University in 1944, he moved across town for postdoctoral work with Herman Mark at the Polytechnic Institute of Brooklyn, where he began his research on light scattering.[5]

Career

In 1946 he took a position at UC Berkeley, where he continued the work on light scattering and invented the famous Zimm plot for determining both size (molecular weight) and shape factors for large molecules. He then spent most of the 1950's at the General Electric Research Laboratory in Schenectady, New York. After a brief stint as a visiting professor at Yale in 1960, he moved to the University of California, San Diego (UCSD), where he remained for the rest of his life.[5]

Research

In 1956, Zimm extended the Rouse model of Polymer Physics to include hydrodynamic interactions mediated by the solvent between different parts of the chain.[7] Whilst the original Rouse model overestimates the decrease of the diffusion coefficient D with the number of polymer beads N as 1/N, the Zimm model predicts D~1/Nν which is consistent with the experimental data for dilute polymer solutions, and where ν is the Flory exponent, a measure of the polymer solubility.

In 1959, together with J.K. Bragg, Zimm wrote a classic paper on the helix-coil transition for polypeptides;[8] a year later he published a second paper on the “melting” of the helical forms of DNA.[9]

See also

References
  1. "APS Fellow Archive". American Physical Society. (search on year 1953 and institution General Electric)
  2. "Brunuo H. Zimm". Membership Directory, National Academy of Sciences.
  3. Doolittle, Russell F. (2009). "Bruno H. Zimm (1920-2005)". Protein Science. 15 (4): 942–944. doi:10.1002/pro.150942. PMC 2242470.
  4. Elson, Elliot L.; Qian, Hong; Schurr, J. Mickey (2006). "Bruno H. Zimm (1920–2005)". Biophysical Chemistry. 121 (2): 155. doi:10.1016/j.bpc.2006.01.001.
  5. Doolittle, RF (2006). "Bruno H. Zimm (1920–2005)". Protein Science. 15 (4): 942–944. doi:10.1002/pro.150942. PMC 2242470.
  6. "Sill Society Recognizes Four New Inductees in 2010", Kent Quarterly, vol. XXXVI.3, Summer 2010, p. 42.
  7. Bruno H. Zimm, Dynamics of Polymer Molecules in Dilute Solution: Viscoelasticity, Flow Birefringence and Dielectric Loss, J. Chem. Phys. 24, 269 (1956).
  8. Zimm, BH; Bragg JK (1959). "Theory of the Phase Transition between Helix and Random Coil in Polypeptide Chains". Journal of Chemical Physics. 31 (2): 526–531. Bibcode:1959JChPh..31..526Z. doi:10.1063/1.1730390.
  9. Zimm, BH (1960). "Theory of "Melting" of the helical form in double chains of the DNA type". Journal of Chemical Physics. 33 (5): 1349–1356. Bibcode:1960JChPh..33.1349Z. doi:10.1063/1.1731411.


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