Butoxyacetic acid

Butoxyacetic acid is an aliphatic organic chemical. It is a liquid.[2] It has the formula C6H12O3 and CAS Registry Number of 2516-93-0.[3] It is REACH registered with the EC number 677-344-8.[4] n-Butyl glycidyl ether is metabolized renally to this compound as is 2-butoxyethanol.[5][6] Methods have been developed and papers published to detect the compound in urine and blood.[7][8][9][10]

Butoxyacetic acid
Names
IUPAC name
2-butoxyacetic acid
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.202.503
EC Number
  • 677-364-8
  • InChI=1S/C6H12O3/c1-2-3-4-9-5-6(7)8/h2-5H2,1H3,(H,7,8)
    Key: AJQOASGWDCBKCJ-UHFFFAOYSA-N
  • CCCCOCC(=O)O
Hazards
GHS labelling:[1]
GHS05: Corrosive
Warning
H290, H314
P234, P260, P264, P264+P265, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P363, P390, P405, P406, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Uses

It is used as a biocide.[11]

References
  1. "Butoxyacetic acid". pubchem.ncbi.nlm.nih.gov.
  2. "Butoxyacetic Acid 2516-93-0 | TCI AMERICA". www.tcichemicals.com. Retrieved 2023-09-13.
  3. "AF6672500 | C6H12O3 | ChemSpider". www.chemspider.com. Retrieved 2023-09-13.
  4. PubChem. "Butoxyacetic acid". pubchem.ncbi.nlm.nih.gov. Retrieved 2023-09-13.
  5. Dill, Jeffrey A.; Lee, Kyeonghee M.; Bates, Derrick J.; Anderson, David J.; Johnson, Renee E.; Chou, Billy J.; Burka, Leo T.; Roycroft, Joseph H. (1998-12-01). "Toxicokinetics of Inhaled 2-Butoxyethanol and Its Major Metabolite, 2-Butoxyacetic Acid, in F344 Rats and B6C3F1 Mice". Toxicology and Applied Pharmacology. 153 (2): 227–242. doi:10.1006/taap.1998.8524. ISSN 0041-008X. PMID 9878593.
  6. Eadsforth, C. V.; Hutson, D. H.; Logan, C. J.; Morrison, B. J. (1985). "The metabolism of n-butyl glycidyl ether in the rat and rabbit". Xenobiotica. 15 (7): 579–89. doi:10.3109/00498258509045887. PMID 4049898.
  7. "Butoxy acetic acid in urine" (PDF). NIOSH.Gov.
  8. Udden, M. M. (2002). "In Vitro Sub-Hemolytic Effects of Butoxyacetic Acid on Human and Rat Erythrocytes". Toxicological Sciences. 69 (1): 258–264. doi:10.1093/toxsci/69.1.258. PMID 12215681. Retrieved 2023-09-13.
  9. Rettenmeier, A. W.; Hennigs, R.; Wodarz, R. (1993-01-01). "Determination of butoxyacetic acid and N-butoxyacetyl-glutamine in urine of lacquerers exposed to 2-butoxyethanol". International Archives of Occupational and Environmental Health. 65 (1): S151–S153. doi:10.1007/BF00381329. ISSN 1432-1246. PMID 8406915. S2CID 514665.
  10. BEGEROW, J; HEINRICH-RAMM, R.; ANGERER, J. (1988). "Determination of butoxyacetic acid in urine by capillary gas chromatography". Determination of Butoxyacetic Acid in Urine by Capillary Gas Chromatography. 331 (8): 818–820. doi:10.1007/BF00469456. ISSN 0016-1152. S2CID 92334305.
  11. "2-Butoxyacetic acid". www.biosynth.com. Retrieved 2023-09-13.
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