CEBPE

CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CRP1, is a type of ccaat-enhancer-binding protein. CEBPE is its human gene[5][6] and is pro-apoptotic.[7]

CEBPE
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCEBPE, C/EBP-epsilon, CRP1, CCAAT/enhancer binding protein epsilon, CCAAT enhancer binding protein epsilon, c/EBP epsilon
External IDsOMIM: 600749 MGI: 103572 HomoloGene: 1367 GeneCards: CEBPE
Orthologs
SpeciesHumanMouse
Entrez

1053

110794

Ensembl

ENSG00000092067

ENSMUSG00000052435

UniProt

Q15744

Q6PZD9

RefSeq (mRNA)

NM_001805

NM_207131

RefSeq (protein)

NP_001796

NP_997014

Location (UCSC)Chr 14: 23.12 – 23.12 MbChr 14: 54.95 – 54.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-δ. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with specific granule deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000092067 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000052435 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon".
  6. Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (Jul 1996). "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus". Genomics. 35 (1): 30–8. doi:10.1006/geno.1996.0319. PMID 8661101.
  7. Nakajima H, Watanabe N, Shibata F, Kitamura T, Ikeda Y, Handa M (May 2006). "N-terminal region of CCAAT/enhancer-binding protein epsilon is critical for cell cycle arrest, apoptosis, and functional maturation during myeloid differentiation". The Journal of Biological Chemistry. 281 (20): 14494–502. doi:10.1074/jbc.M600575200. PMID 16531405.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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