C5orf45

Chromosome 5 open reading frame 45 is a protein that in humans is encoded by the C5orf45 gene.[1] The orthologue in mice is 3010026O09Rik.[1]

Model organisms

*3010026O09Rik* knockout mouse phenotype
Characteristic	Phenotype
Homozygote viability	Normal
Fertility	Abnormal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology	Normal
Micronucleus test	Normal
Heart weight	Normal
Tail epidermis wholemount	Normal
Skin Histopathology	Normal
Brain histopathology	Normal
Eye Histopathology	Normal
Salmonella infection	Normal[2]
Citrobacter infection	Normal[3]
All tests and analysis from[4][5]

Model organisms have been used in the study of C5orf45 function. A conditional knockout mouse line, called 3010026O09Rik^{tm1a(EUCOMM)Wtsi}[6][7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[8][9][10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4][11] Twenty five tests were carried out on mutant mice and one significant abnormality was observed: male homozygote mutants were infertile.[4]

References

"Chromosome 5 open reading frame 45". Retrieved 2011-12-07.
"Salmonella infection data for 3010026O09Rik". Wellcome Trust Sanger Institute.
"Citrobacter infection data for 3010026O09Rik". Wellcome Trust Sanger Institute.
Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
Mouse Resources Portal, Wellcome Trust Sanger Institute.
"International Knockout Mouse Consortium".
"Mouse Genome Informatics".
Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Wiemann, S.; Arlt, D.; Huber, W.; Wellenreuther, R.; Schleeger, S.; Mehrle, A.; Bechtel, S.; Sauermann, M.; Korf, U.; Pepperkok, R.; Sültmann, H.; Poustka, A. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Research. 14 (10b): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Lamesch, P.; Li, N.; Milstein, S.; Fan, C.; Hao, T.; Szabo, G.; Hu, Z.; Venkatesan, K.; Bethel, G.; Martin, P.; Rogers, J.; Lawlor, S.; McLaren, S.; Dricot, A. L.; Borick, H.; Cusick, M. E.; Vandenhaute, J.; Dunham, I.; Hill, D. E.; Vidal, M. (2007). "HORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes". Genomics. 89 (3): 307–315. doi:10.1016/j.ygeno.2006.11.012. PMC 4647941. PMID 17207965.

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[entrez-1] "Chromosome 5 open reading frame 45". Retrieved 2011-12-07.

[''Salmonella''_infection-2] "Salmonella infection data for 3010026O09Rik". Wellcome Trust Sanger Institute.

[''Citrobacter''_infection-3] "Citrobacter infection data for 3010026O09Rik". Wellcome Trust Sanger Institute.

[mgp_reference-4] Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.

[5] Mouse Resources Portal, Wellcome Trust Sanger Institute.

[allele_ref-6] "International Knockout Mouse Consortium".

[mgi_allele_ref-7] "Mouse Genome Informatics".

[pmid21677750-8] Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.

[mouse_library-9] Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.

[mouse_for_all_reasons-10] Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.

[pmid21722353-11] van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

C5orf45

Model organisms

References

Further reading