C6orf62

Chromosome 6 open reading frame 62 (C6orf62), also known as X-trans-activated protein 12 (XTP12),[5] is a gene that encodes a protein of the same name. The encoded protein is predicted to have a subcellular location within the cytosol.[6]

C6orf62
Identifiers
AliasesC6orf62, Nbla00237, XTP12, dJ30M3.2, chromosome 6 open reading frame 62
External IDsMGI: 2441726 HomoloGene: 11551 GeneCards: C6orf62
Orthologs
SpeciesHumanMouse
Entrez

81688

79555

Ensembl

ENSG00000112308

ENSMUSG00000019132

UniProt

Q9GZU0

Q99LU8

RefSeq (mRNA)

NM_030939

NM_024473

RefSeq (protein)

NP_112201

NP_077793

Location (UCSC)Chr 6: 24.7 – 24.72 MbChr 13: 24.99 – 25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gene and Transcript

In the DNA, C6orf62 is 12,529 base pairs long and is located at 6q22.3.[7] It is located on chromosome 6 on position 22.3 (6q22.3). The mature mRNA sequence is 2498 base-pairs long with 5 exons and 4 intronic regions that translates a protein that is 229 amino acids long and two predicted isoforms of 160 amino acids and 200 amino acids.[8][9]


Protein

The main transcript is 229 amino acids long and is encoded from 5 exonic regions. There exists two transcript variants that are 200 amino acids and 160 amino acids long. There is a domain of unknown function (DUF4566) present in all three variants and spans positions 1–226 on the main transcript.[10] The molecular weight of C6orf62 is 27.1 kDa and its isoelectric point is at a pH of 9.24.[11] It is located subcellularly localized throughout the cytosol.[6]

Protein Interactions
Protein
ELAVL1 predicted through affinity capture-RNA.[12]
PVRL4 predicted through affinity capture-mass spectroscopy.[12]
NADH predicted through yeast two-hybrid screening.[13]

Expression

C6orf62 is broadly expressed within the human body, however, its protein abundance is not high.[14] It is more heavily expressed in the gallbladder and testis, but it is not predicted to be expressed in the smooth muscle, lymph nodes, the spleen, ovaries, adipose tissue, and soft tissue.

Homology

C6orf62 is highly conserved among vertebrates and has orthologs found in invertebrates.

Orthologs in Select Mammals
Genus Species Common Name Date of divergence (MYA) RefSeq AA Length % Identity % Similarity
Pongo abelii Sumatran Orangutan 15.2 NP_001126883.1 232 99 99
Ictidomys tridecemlineatus Ground Squirrel 88 XP_005337081.1 231 99 98
Tupaia chinensis Treeshrew 85 XP_006162754.1 267 84 98
Rattus norvegicus Brown Rat 88 NP_001017510.1 232 99 98

[15]

Orthologs in Select Ray-Finned Fish
Genus Species Common Name Date of divergence (MYA) RefSeq AA Length % Identity % Similarity
Salmo salar Salmon 435 XP_014034327.1 233 82 93
Sinocyclocheilus rhinoceros Golden-lined Barbell 435 XP_016388718.1 230 87 94
Hippocampus comes Seahorse 435 XP_019729847.1 234 80 91

[15]

Orthologs in Select Amphibians
Genus Species Common Name Date of divergence (MYA) RefSeq AA Length % Identity % Similarity
Nanorana parkeri High Himalaya Frog 353 XP_018411819.1 232 95 97
Xenopus trpocalis African Clawed Frog 353 NP_001120278.1 232 93 98

[15]

Orthologs in Select Reptiles
Genus Species Common Name Date of divergence (MYA) RefSeq AA Length % Identity % Similarity
Chrysemys picta belli Painted Turtle 320 XP_005281462.1 233 97 98
Python vbivittatus Burmese Python 320 XP_007521998.1 233 96 99
Chelonia mydas Green Sea Turtle 320 XP_007060449.1 231 97 98
Alligator sinensis Chinese Alligator 320 XP_006034488.1 232 98 99

[15]

Orthologs in Select Birds
Genus Species Common Name Date of divergence (MYA) RefSeq AA Length % Identity % Similarity
Tauraco erythrolophus Red-crested Tauraco 320 XP_009991398.1 232 97
Taeniopygia guttata Zebra Finch 320 XP_002194166.1 232 98
Manacus vitellinus Gold Marked Manakin 320 XP_017925511.1 241 98

Orthologs in Select Invertebrates[15]

Genus Species Common Name Date of divergence (MYA) RefSeq AA Length % Identity % Similarity
Ciona intestinalis Sea Squirt 677 XP_002119736.1 233 38 62
Crassostrea gigas Pacific Oyster 758 XP_011438527.1 231 62 80
Hellobdella robusta Glossiphoniidae Leech 758 XP_009016977.1 264 35 51
Octopus bimaculoides Two-Spot Octopus 758 XP_014780369.1 197 60 79
Saccoglossus kowalevskii Acorn Worm 627 XP_002741666.1 230 66 83

[15]

References
  1. GRCh38: Ensembl release 89: ENSG00000112308 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000019132 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Database, GeneCards Human Gene. "C6orf62 Gene - GeneCards | CF062 Protein | CF062 Antibody". www.genecards.org. Retrieved 2017-02-21.
  6. "Tissue expression of C6orf62 - Summary - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2017-05-08.
  7. Kent, WJ; Sugnet, CW; Furey, TS; Roskin, KM; Pringle, TH; Zahler, AM; Haussler, D (2002). "UCSC Genome Browser". UCSC Genome Browser. Retrieved 2017-02-20.
  8. "PREDICTED: uncharacterized protein C6orf62 isoform X1 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2017-05-08.
  9. "PREDICTED: uncharacterized protein C6orf62 isoform X2 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2017-05-08.
  10. "C6orf62 chromosome 6 open reading frame 62 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2017-05-08.
  11. Volker, Brendel (2006). "SAPS - SDSC Bio Workbench". SDSC Biology Workbench. Retrieved 2017-05-01.
  12. Lab, Mike Tyers. "C6orf62 (RP1-30M3.4) Result Summary | BioGRID". thebiogrid.org. Retrieved 2017-05-08.
  13. "1 binary interaction found for search term C6orf62". IntAct Molecular Interaction Database. EMBL-EBI. Retrieved 2018-08-25.
  14. "C6orf62 protein abundance in PaxDb". pax-db.org. Retrieved 2017-05-08.
  15. "NCBI - Basic Local Alignment Search Tool". NCBI.
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