CAMSAP3

Calmodulin-regulated spectrin-associated protein family member 3 (CAMSAP3) is a human protein encoded by the gene CAMSAP3. The protein is commonly referred to as Nezha.

CAMSAP3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCAMSAP3, KIAA1543, NEZHA, PPP1R80, calmodulin regulated spectrin associated protein family member 3
External IDsOMIM: 612685 MGI: 1916947 HomoloGene: 18966 GeneCards: CAMSAP3
Orthologs
SpeciesHumanMouse
Entrez

57662

69697

Ensembl

ENSG00000076826

ENSMUSG00000044433

UniProt

Q9P1Y5

Q80VC9

RefSeq (mRNA)

NM_001080429
NM_020902

NM_001163749
NM_027171
NM_001347111
NM_001347112
NM_001347113

RefSeq (protein)

NP_001073898
NP_065953

Location (UCSC)Chr 19: 7.6 – 7.62 MbChr 8: 3.59 – 3.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

CAMSAP3 acts as a minus-end anchor of microtubules, and binds to them through its CKK domain.[5]

In epithelial cells, it anchors microtubules to the apical cortex, causing them to grow in an apical-to-basal direction.[6] This gives the epithelial cells their rectangular shape.

In early mouse embryogenesis, the interphase bridge linking sister cells is enriched with CAMSAP3.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000076826 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000044433 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Baines, A. J.; Bignone, P. A.; King, M. D.A.; Maggs, A. M.; Bennett, P. M.; Pinder, J. C.; Phillips, G. W. (2009-09-01). "The CKK Domain (DUF1781) Binds Microtubules and Defines the CAMSAP/ssp4 Family of Animal Proteins". Molecular Biology and Evolution. 26 (9): 2005–2014. doi:10.1093/molbev/msp115. ISSN 0737-4038. PMID 19508979. Archived from the original on 2022-06-15. Retrieved 2022-09-29.
  6. Toya M, Kobayashi S, Kawasaki M, Shioi G, Kaneko M, Ishiuchi T, et al. (January 2016). "CAMSAP3 orients the apical-to-basal polarity of microtubule arrays in epithelial cells". Proceedings of the National Academy of Sciences of the United States of America. 113 (2): 332–337. Bibcode:2016PNAS..113..332T. doi:10.1073/pnas.1520638113. PMC 4720291. PMID 26715742.
  7. Zenker J, White MD, Templin RM, Parton RG, Thorn-Seshold O, Bissiere S, Plachta N (September 2017). "A microtubule-organizing center directing intracellular transport in the early mouse embryo". Science. 357 (6354): 925–928. Bibcode:2017Sci...357..925Z. doi:10.1126/science.aam9335. PMID 28860385. S2CID 206658036.
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