Macrophage-capping protein

Macrophage-capping protein (CAPG) also known as actin regulatory protein CAP-G is a protein that in humans is encoded by the CAPG gene.[5][6][7]

CAPG
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCAPG, AFCP, HEL-S-66, MCP, capping actin protein, gelsolin like
External IDsOMIM: 153615 MGI: 1098259 HomoloGene: 37523 GeneCards: CAPG
Orthologs
SpeciesHumanMouse
Entrez

822

12332

Ensembl

ENSG00000042493

ENSMUSG00000056737

UniProt

P40121

P24452

RefSeq (mRNA)

NM_001042534
NM_001271395
NM_001271415
NM_007599

RefSeq (protein)

n/a

Location (UCSC)Chr 2: 85.39 – 85.42 MbChr 6: 72.52 – 72.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins.[8] The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively, spliced transcript variants have been observed, but have not been fully described.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000042493 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000056737 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dabiri GA, Young CL, Rosenbloom J, Southwick FS (Sep 1992). "Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages". J Biol Chem. 267 (23): 16545–52. doi:10.1016/S0021-9258(18)42037-6. PMID 1322908.
  6. Pellieux C, Desgeorges A, Pigeon CH, Chambaz C, Yin H, Hayoz D, Silacci P (Jul 2003). "Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress". J Biol Chem. 278 (31): 29136–44. doi:10.1074/jbc.M300598200. PMID 12754261.
  7. "Entrez Gene: CAPG capping protein (actin filament), gelsolin-like".
  8. Ghoshdastider, U; Popp, D; Burtnick, L. D.; Robinson, R. C. (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256. S2CID 205643538.

Further reading


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