CASC3

Protein CASC3 is a protein that in humans is encoded by the CASC3 gene.[5][6][7]

CASC3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCASC3, BTZ, MLN51, cancer susceptibility candidate 3, cancer susceptibility 3, exon junction complex subunit, CASC3 exon junction complex subunit
External IDsOMIM: 606504 MGI: 2179723 HomoloGene: 7208 GeneCards: CASC3
Orthologs
SpeciesHumanMouse
Entrez

22794

192160

Ensembl

ENSG00000108349

ENSMUSG00000078676

UniProt

O15234

Q8K3W3

RefSeq (mRNA)

NM_007359

NM_138660

RefSeq (protein)

NP_031385

NP_619601

Location (UCSC)Chr 17: 40.14 – 40.17 MbChr 11: 98.7 – 98.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000108349 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000078676 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tomasetto C, Regnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC (Jan 1996). "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17". Genomics. 28 (3): 367–76. doi:10.1006/geno.1995.1163. PMID 7490069.
  6. Arriola E, Marchio C, Tan DS, Drury SC, Lambros MB, Natrajan R, Rodriguez-Pinilla SM, Mackay A, Tamber N, Fenwick K, Jones C, Dowsett M, Ashworth A, Reis-Filho JS (Apr 2008). "Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines". Lab Invest. 88 (5): 491–503. doi:10.1038/labinvest.2008.19. PMID 18332872.
  7. "Entrez Gene: CASC3 cancer susceptibility candidate 3".

Further reading


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