CBX7 (gene)

Chromobox homolog 7 is a protein that in humans is encoded by the CBX7 gene.[5] The loss of CBX7 gene expression has been shown to correlate with a malignant form of thyroid cancer.[6]

CBX7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCBX7, chromobox 7
External IDsOMIM: 608457 MGI: 1196439 HomoloGene: 65296 GeneCards: CBX7
Orthologs
SpeciesHumanMouse
Entrez

23492

52609

Ensembl

ENSG00000100307

ENSMUSG00000053411

UniProt

O95931

Q8VDS3

RefSeq (mRNA)

NM_175709
NM_001346743
NM_001346744

NM_144811

RefSeq (protein)

NP_001333672
NP_001333673
NP_783640
NP_783640.1

NP_659060

Location (UCSC)Chr 22: 39.12 – 39.15 MbChr 15: 79.8 – 79.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Model organisms

Model organisms have been used in the study of CBX7 function. A conditional knockout mouse line, called Cbx7tm1a(KOMP)Wtsi[13][14] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[15][16][17] Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[11][18] Twenty six tests were carried out and three significant phenotypes were reported. Homozygous mutant female adults showed a decreased response to stress-induced hyperthermia and had an increased red blood cell count. Animals of both sex had an integument phenotype when tail epidermis was examined.[11]

References
  1. GRCh38: Ensembl release 89: ENSG00000100307 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000053411 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Chromobox homolog 7". Retrieved 2011-12-06.
  6. Pallante P, Federico A, Berlingieri MT, Bianco M, Ferraro A, Forzati F, et al. (August 2008). "Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer". Cancer Research. 68 (16): 6770–8. doi:10.1158/0008-5472.CAN-08-0695. PMID 18701502.
  7. "Body temperature data for Cbx7". Wellcome Trust Sanger Institute.
  8. "Haematology data for Cbx7". Wellcome Trust Sanger Institute.
  9. "Salmonella infection data for Cbx7". Wellcome Trust Sanger Institute.
  10. "Citrobacter infection data for Cbx7". Wellcome Trust Sanger Institute.
  11. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  12. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  13. "International Knockout Mouse Consortium". Archived from the original on 2012-03-20. Retrieved 2012-01-05.
  14. "Mouse Genome Informatics".
  15. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, et al. (June 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  16. Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  17. Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  18. van der Weyden L, White JK, Adams DJ, Logan DW (June 2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading


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