CCT7

T-complex protein 1 subunit eta is a protein that in humans is encoded by the CCT7 gene.[5][6]

CCT7
Identifiers
AliasesCCT7, CCTETA, CCTH, NIP7-1, TCP1ETA, chaperonin containing TCP1 subunit 7
External IDsOMIM: 605140 MGI: 107184 HomoloGene: 4694 GeneCards: CCT7
Orthologs
SpeciesHumanMouse
Entrez

10574

12468

Ensembl

ENSG00000135624

ENSMUSG00000030007

UniProt

Q99832

P80313

RefSeq (mRNA)

NM_001009570
NM_001166284
NM_001166285
NM_006429

NM_007638

RefSeq (protein)

NP_001009570
NP_001159756
NP_001159757
NP_006420

NP_031664

Location (UCSC)Chr 2: 73.23 – 73.25 MbChr 6: 85.43 – 85.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a molecular chaperone that is a member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date.[6]

Interactions

CCT7 has been shown to interact with PPP4C.[7][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000135624 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030007 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Won KA, Schumacher RJ, Farr GW, Horwich AL, Reed SI (Dec 1998). "Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT". Molecular and Cellular Biology. 18 (12): 7584–9. doi:10.1128/mcb.18.12.7584. PMC 109339. PMID 9819444.
  6. "Entrez Gene: CCT7 chaperonin containing TCP1, subunit 7 (eta)".
  7. Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
  8. Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.

Further reading


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