Cytidine deaminase

Cytidine deaminase is an enzyme that in humans is encoded by the CDA gene.[5][6][7]

CDA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCDA, CDD, cytidine deaminase
External IDsOMIM: 123920 MGI: 1919519 HomoloGene: 1352 GeneCards: CDA
Orthologs
SpeciesHumanMouse
Entrez

978

72269

Ensembl

ENSG00000158825

ENSMUSG00000028755

UniProt

P32320

P56389

RefSeq (mRNA)

NM_001785

NM_028176

RefSeq (protein)

NP_001776

NP_082452

Location (UCSC)Chr 1: 20.59 – 20.62 MbChr 4: 138.07 – 138.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.[7] Most cytidine deaminases act on RNA, and the few that act on DNA require ssDNA.[8]

A related activation-induced (cytidine) deaminase (AID) regulates antibody diversification, especially the process of somatic hypermutation.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

[[File:
FluoropyrimidineActivity_WP1601
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FluoropyrimidineActivity_WP1601
|alt=Fluorouracil (5-FU) Activity edit]]
Fluorouracil (5-FU) Activity edit
  1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

References

  1. GRCh38: Ensembl release 89: ENSG00000158825 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028755 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kühn K, Bertling WM, Emmrich F (January 1993). "Cloning of a functional cDNA for human cytidine deaminase (CDD) and its use as a marker of monocyte/macrophage differentiation". Biochemical and Biophysical Research Communications. 190 (1): 1–7. doi:10.1006/bbrc.1993.1001. PMID 8422236.
  6. Demontis S, Terao M, Brivio M, Zanotta S, Bruschi M, Garattini E (December 1998). "Isolation and characterization of the gene coding for human cytidine deaminase". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1443 (3): 323–33. doi:10.1016/s0167-4781(98)00235-8. PMID 9878810.
  7. "Entrez Gene: CDA cytidine deaminase".
  8. Komor AC, Kim YB, Packer MS, Zuris JA, Liu DR (May 2016). "Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage". Nature. 533 (7603): 420–4. Bibcode:2016Natur.533..420K. doi:10.1038/nature17946. PMC 4873371. PMID 27096365.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: P32320 (Cytidine deaminase) at the PDBe-KB.
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