CDC23

Cell division cycle 23 homolog (S. cerevisiae), also known as CDC23, is a protein that, in humans, is encoded by the CDC23 gene.[5]

CDC23
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCDC23, ANAPC8, APC8, CUT23, cell division cycle 23
External IDsOMIM: 603462 MGI: 1098815 HomoloGene: 3426 GeneCards: CDC23
Orthologs
SpeciesHumanMouse
Entrez

8697

52563

Ensembl

ENSG00000094880

ENSMUSG00000024370

UniProt

Q9UJX2

Q8BGZ4

RefSeq (mRNA)

NM_004661

NM_178347

RefSeq (protein)

NP_004652

NP_848124

Location (UCSC)Chr 5: 138.19 – 138.21 MbChr 18: 34.76 – 34.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The CDC23 protein shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.[5]

Interactions

CDC23 has been shown to interact with CDC27.[6][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000094880 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024370 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CDC23 cell division cycle 23 homolog (S. cerevisiae)".
  6. Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (Sep 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947.
  7. Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (Aug 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.

Further reading


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