CDC42EP4

Cdc42 effector protein 4 is a protein that in humans is encoded by the CDC42EP4 gene.[5][6][7]

CDC42EP4
Identifiers
AliasesCDC42EP4, BORG4, CEP4, KAIA1777, CDC42 effector protein 4
External IDsOMIM: 605468 MGI: 1929760 HomoloGene: 8110 GeneCards: CDC42EP4
Orthologs
SpeciesHumanMouse
Entrez

23580

56699

Ensembl

ENSG00000179604

ENSMUSG00000041598

UniProt

Q9H3Q1

Q9JM96

RefSeq (mRNA)

NM_012121

NM_001163346
NM_020006

RefSeq (protein)

NP_036253

NP_001156818
NP_064390

Location (UCSC)Chr 17: 73.28 – 73.31 MbChr 11: 113.62 – 113.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000179604 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000041598 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hirsch DS, Pirone DM, Burbelo PD (Mar 2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes". J Biol Chem. 276 (2): 875–83. doi:10.1074/jbc.M007039200. PMID 11035016.
  6. Joberty G, Perlungher RR, Macara IG (Feb 2000). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Mol Cell Biol. 19 (10): 6585–97. doi:10.1128/MCB.19.10.6585. PMC 84628. PMID 10490598.
  7. "Entrez Gene: CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.