CDK5R2

Cyclin-dependent kinase 5 activator 2 is an enzyme that in humans is encoded by the CDK5R2 gene.[5][6]

CDK5R2
Identifiers
AliasesCDK5R2, NCK5AI, P39, p39nck5ai, cyclin-dependent kinase 5, regulatory subunit 2 (p39), cyclin dependent kinase 5 regulatory subunit 2
External IDsOMIM: 603764 MGI: 1330828 HomoloGene: 2924 GeneCards: CDK5R2
Orthologs
SpeciesHumanMouse
Entrez

8941

12570

Ensembl

ENSG00000171450

ENSMUSG00000090071

UniProt

Q13319

O35926

RefSeq (mRNA)

NM_003936

NM_009872

RefSeq (protein)

NP_003927

NP_034002

Location (UCSC)Chr 2: 218.96 – 218.96 MbChr 1: 74.89 – 74.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase-activating proteins.[6]

Interactions

CDK5R2 has been shown to interact with Actinin, alpha 1.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000171450 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000090071 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tang D, Yeung J, Lee KY, Matsushita M, Matsui H, Tomizawa K, Hatase O, Wang JH (November 1995). "An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator". The Journal of Biological Chemistry. 270 (45): 26897–903. doi:10.1074/jbc.270.45.26897. PMID 7592934.
  6. "Entrez Gene: CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)".
  7. Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai LH (September 2002). "The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner". The Journal of Neuroscience. 22 (18): 7879–91. doi:10.1523/JNEUROSCI.22-18-07879.2002. PMC 6758084. PMID 12223541.

طراحی سایت فروشگاهی

Further reading


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