CELA1

Chymotrypsin-like elastase family member 1 (CELA1) also known as elastase-1 (ELA1) is an enzyme that in humans is encoded by the CELA1 gene. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B.

CELA1
Identifiers
AliasesCELA1, ELA1, chymotrypsin like elastase family member 1, chymotrypsin like elastase 1
External IDsOMIM: 130120 MGI: 95314 HomoloGene: 20454 GeneCards: CELA1
Orthologs
SpeciesHumanMouse
Entrez

1990

109901

Ensembl

ENSG00000139610

ENSMUSG00000023031

UniProt

Q9UNI1

Q91X79

RefSeq (mRNA)

NM_001971

NM_033612

RefSeq (protein)

NP_001962

NP_291090

Location (UCSC)Chr 12: 51.33 – 51.35 MbChr 15: 100.57 – 100.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tissue distribution

Elastase-1 was formerly designated pancreatic elastase 1. However unlike other elastases, pancreatic elastase 1 is not expressed in the pancreas. Hence this enzyme has been renamed as elastase-1. To date, elastase 1 expression has only been detected in skin keratinocytes. Literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase family, member 3B CELA3B).

Clinical significance

This enzyme has been linked to chronic pancreatitis .[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000139610 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000023031 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Gullo L, Ventrucci M, Tomassetti P, Migliori M, Pezzilli R (January 1999). "Fecal elastase 1 determination in chronic pancreatitis". Digestive Diseases and Sciences. 44 (1): 210–3. doi:10.1023/A:1026691209094. PMID 9952246. S2CID 1137506.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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