CELA2A

Chymotrypsin-like elastase family member 2A is an enzyme that in humans is encoded by the CELA2A gene.[5][6][7]

CELA2A
Identifiers
AliasesCELA2A, ELA2A, PE-1, chymotrypsin like elastase family member 2A, chymotrypsin like elastase 2A, AOMS4
External IDsOMIM: 609443 MGI: 95316 HomoloGene: 40598 GeneCards: CELA2A
Orthologs
SpeciesHumanMouse
Entrez

63036

13706

Ensembl

ENSG00000142615

ENSMUSG00000058579

UniProt

P08217

P05208

RefSeq (mRNA)

NM_033440

NM_007919

RefSeq (protein)

NP_254275

NP_031945

Location (UCSC)Chr 1: 15.46 – 15.47 MbChr 4: 141.54 – 141.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. Clinical literature that describes human elastase 1 activity in the pancreas is actually referring to elastase 2A.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000142615 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000058579 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kawashima I, Tani T, Shimoda K, Takiguchi Y (Jul 1987). "Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas". DNA. 6 (2): 163–72. doi:10.1089/dna.1987.6.163. PMID 3646943.
  6. Shirasu Y, Yoshida H, Matsuki S, Takemura K, Ikeda N, Shimada Y, Ozawa T, Mikayama T, Iijima H, Ishida A, et al. (Jun 1988). "Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2". J Biochem. 102 (6): 1555–63. doi:10.1093/oxfordjournals.jbchem.a122204. PMID 2834346.
  7. "Entrez Gene: ELA2A elastase 2A".

Further reading


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