CENTD2

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ARAP1 gene.[5]

ARAP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARAP1, CENTD2, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1, cnt-d2
External IDsOMIM: 606646 MGI: 1916960 HomoloGene: 12326 GeneCards: ARAP1
Orthologs
SpeciesHumanMouse
Entrez

116985

69710

Ensembl

ENSG00000186635

ENSMUSG00000032812

UniProt

Q96P48

Q4LDD4

RefSeq (mRNA)

NM_015242
NM_001040118
NM_001135190
NM_001369489

NM_001040111
NM_001040112
NM_027180
NM_198096

RefSeq (protein)

NP_001035207
NP_001128662
NP_056057
NP_001356418

Location (UCSC)Chr 11: 72.69 – 72.79 MbChr 7: 101 – 101.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. The RHO-GAP activity may mediate cell rounding and loss of stress fibers. At least three transcript variants encoding different isoforms have been found for this gene, but the full-length natures of all variants have not been determined.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000186635 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032812 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CENTD2 centaurin, delta 2".

Further reading

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