CENTD3

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 is a protein that in humans is encoded by the ARAP3 gene.[5][6][7]

ARAP3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARAP3, CENTD3, DRAG1, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
External IDsOMIM: 606647 MGI: 2147274 HomoloGene: 11199 GeneCards: ARAP3
Orthologs
SpeciesHumanMouse
Entrez

64411

106952

Ensembl

ENSG00000120318

ENSMUSG00000024451

UniProt

Q8WWN8

Q8R5G7

RefSeq (mRNA)

NM_022481

NM_001205336
NM_139206

RefSeq (protein)

NP_071926

NP_001192265
NP_631945

Location (UCSC)Chr 5: 141.65 – 141.68 MbChr 18: 38.11 – 38.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its full-length nature has not been determined.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000120318 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024451 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor A, Coadwell J, Davidson K, Eguinoa A, Ellson CD, Lipp P, Manifava M, Ktistakis N, Painter G, Thuring JW, Cooper MA, Lim ZY, Holmes AB, Dove SK, Michell RH, Grewal A, Nazarian A, Erdjument-Bromage H, Tempst P, Stephens LR, Hawkins PT (Jan 2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Mol Cell. 9 (1): 95–108. doi:10.1016/S1097-2765(02)00434-3. PMID 11804589.
  6. Santy LC, Casanova JE (May 2002). "GTPase signaling: bridging the GAP between ARF and Rho". Curr Biol. 12 (10): R360–2. doi:10.1016/S0960-9822(02)00860-6. PMID 12015138. S2CID 15875666.
  7. "Entrez Gene: CENTD3 centaurin, delta 3".

Further reading


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