CHSY1

Chondroitin sulfate synthase 1 is an enzyme that in humans is encoded by the CHSY1 gene.[5][6]

CHSY1
Identifiers
AliasesCHSY1, CHSY, CSS1, ChSy-1, TPBS, chondroitin sulfate synthase 1
External IDsOMIM: 608183 MGI: 2681120 HomoloGene: 8950 GeneCards: CHSY1
Orthologs
SpeciesHumanMouse
Entrez

22856

269941

Ensembl

ENSG00000131873

ENSMUSG00000032640

UniProt

Q86X52

Q6ZQ11

RefSeq (mRNA)

NM_014918

NM_001081163

RefSeq (protein)

NP_055733

NP_001074632

Location (UCSC)Chr 15: 101.18 – 101.25 MbChr 7: 65.76 – 65.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CHSY1 synthesizes chondroitin sulfate, a glycosaminoglycan expressed on the surface of most cells and in extracellular matrices. Glycosaminoglycan chains are covalently linked to a wide range of core protein families and regulate many biologic processes, including cell proliferation and recognition, extracellular matrix deposition, and morphogenesis.[7][6]

References

  1. GRCh38: Ensembl release 89: ENSG00000131873 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032640 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kitagawa H, Uyama T, Sugahara K (Oct 2001). "Molecular cloning and expression of a human chondroitin synthase". J Biol Chem. 276 (42): 38721–6. doi:10.1074/jbc.M106871200. PMID 11514575.
  6. "Entrez Gene: CHSY1 carbohydrate (chondroitin) synthase 1".
  7. supplied by OMIM

Further reading

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