CIDEA

Cell death activator CIDE-A is a protein that in humans is encoded by the CIDEA gene.[5][6][7] Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids.[8]

CIDEA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCIDEA, CIDE-A, cell death-inducing DFFA-like effector a, cell death inducing DFFA like effector a
External IDsOMIM: 604440 MGI: 1270845 HomoloGene: 77852 GeneCards: CIDEA
Orthologs
SpeciesHumanMouse
Entrez

1149

12683

Ensembl

ENSG00000176194

ENSMUSG00000024526

UniProt

O60543

O70302

RefSeq (mRNA)

NM_001279
NM_001318383

NM_007702

RefSeq (protein)

NP_001270
NP_001305312

NP_031728

Location (UCSC)Chr 18: 12.25 – 12.28 MbChr 18: 67.48 – 67.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Two alternative transcripts encoding different isoforms have been identified.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000176194 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024526 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Inohara N, Koseki T, Chen S, Wu X, Nunez G (Jun 1998). "CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor" (PDF). EMBO J. 17 (9): 2526–33. doi:10.1093/emboj/17.9.2526. PMC 1170594. PMID 9564035.
  6. Puri V, Ranjit S, Konda S, Nicoloro SM, Straubhaar J, Chawla A, Chouinard M, Lin C, Burkart A, Corvera S, Perugini RA, Czech MP (Jun 2008). "Cidea is associated with lipid droplets and insulin sensitivity in humans". Proc Natl Acad Sci U S A. 105 (22): 7833–8. Bibcode:2008PNAS..105.7833P. doi:10.1073/pnas.0802063105. PMC 2409392. PMID 18509062.
  7. "Entrez Gene: CIDEA cell death-inducing DFFA-like effector a".
  8. Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids

Further reading


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