CIZ1
Cip1-interacting zinc finger protein is a protein that in humans is encoded by the CIZ1 gene.[5][6]
| CIZ1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | CIZ1, LSFR1, NP94, ZNF356, CDKN1A interacting zinc finger protein 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 611420 MGI: 1920234 HomoloGene: 8112 GeneCards: CIZ1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
The protein encoded by this gene is a zinc finger DNA binding transcription factor that interacts with CIP1 (p21 / CDKN1A), part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1.[6]
Clinical significance
An altered circulating form of the Ciz1 protein is synthesized by lung cancer cells, even when they are at a very early stage. Hence detection of this protein variant in blood could be used as a biomarker for early detection of lung cancer.[7]
Ciz1 mutant mice
Aged (18-mo-old) Ciz1-/- mice have increased neuronal DNA double-strand breaks that likely contributed to their loss of neurons and cognitive decline with age.[8] Embryonic fibroblasts from Ciz1-/- mice show abnormal sensitivity to γ-irradiation with persistent DNA breaks, aberrant cell cycle progression and increased apoptosis.[8]
References
- GRCh38: Ensembl release 89: ENSG00000148337 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000039205 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Mitsui K, Matsumoto A, Ohtsuka S, Ohtsubo M, Yoshimura A (October 1999). "Cloning and characterization of a novel p21(Cip1/Waf1)-interacting zinc finger protein, ciz1". Biochemical and Biophysical Research Communications. 264 (2): 457–64. doi:10.1006/bbrc.1999.1516. PMID 10529385.
- "Entrez Gene: CIZ1 CDKN1A interacting zinc finger protein 1".
- Higgins G, Roper KM, Watson IJ, Blackhall FH, Rom WN, Pass HI, et al. (November 2012). "Variant Ciz1 is a circulating biomarker for early-stage lung cancer". Proceedings of the National Academy of Sciences of the United States of America. 109 (45): E3128-35. doi:10.1073/pnas.1210107109. PMC 3494940. PMID 23074256.
- Khan MM, Xiao J, Patel D, LeDoux MS (February 2018). "DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice". Neurobiology of Aging. 62: 180–190. doi:10.1016/j.neurobiolaging.2017.10.014. PMC 5877805. PMID 29154038.
External links
- Human CIZ1 genome location and CIZ1 gene details page in the UCSC Genome Browser.
Further reading
- Lukasik A, Uniewicz KA, Kulis M, Kozlowski P (January 2008). "Ciz1, a p21 cip1/Waf1-interacting zinc finger protein and DNA replication factor, is a novel molecular partner for human enhancer of rudimentary homolog". The FEBS Journal. 275 (2): 332–40. doi:10.1111/j.1742-4658.2007.06203.x. PMID 18081865. S2CID 35928583.
- Rahman F, Ainscough JF, Copeland N, Coverley D (October 2007). "Cancer-associated missplicing of exon 4 influences the subnuclear distribution of the DNA replication factor CIZ1". Human Mutation. 28 (10): 993–1004. doi:10.1002/humu.20550. PMID 17508423. S2CID 34590449.
- den Hollander P, Rayala SK, Coverley D, Kumar R (November 2006). "Ciz1, a Novel DNA-binding coactivator of the estrogen receptor alpha, confers hypersensitivity to estrogen action". Cancer Research. 66 (22): 11021–9. doi:10.1158/0008-5472.CAN-06-2336. PMID 17108141.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Coverley D, Marr J, Ainscough J (January 2005). "Ciz1 promotes mammalian DNA replication". Journal of Cell Science. 118 (Pt 1): 101–12. doi:10.1242/jcs.01599. PMID 15585571.
- Warder DE, Keherly MJ (2004). "Ciz1, Cip1 interacting zinc finger protein 1 binds the consensus DNA sequence ARYSR(0-2)YYAC". Journal of Biomedical Science. 10 (4): 406–17. doi:10.1159/000071160. PMID 12824700. S2CID 202648843.
- Gilley J, Fried M (July 1999). "Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes". Human Molecular Genetics. 8 (7): 1313–20. doi:10.1093/hmg/8.7.1313. PMID 10369878.
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