CKMT2

Creatine kinase S-type, mitochondrial is an enzyme that in humans is encoded by the CKMT2 gene.[5][6]

CKMT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4Z9M
Identifiers
Aliases	CKMT2, SMTCK, creatine kinase, mitochondrial 2
External IDs	OMIM: 123295 MGI: 1923972 HomoloGene: 68206 GeneCards: CKMT2
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q14.1 Start 81,233,320 bp[1] End 81,266,398 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 C3 Start 92,001,506 bp[2] End 92,025,004 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle gastrocnemius muscle biceps brachii thoracic diaphragm vastus lateralis muscle triceps brachii muscle deltoid muscle body of tongue tibialis anterior muscle vena cava Top expressed in plantaris muscle extraocular muscle interventricular septum soleus muscle digastric muscle extensor digitorum longus muscle tibialis anterior muscle sternocleidomastoid muscle masseter muscle intercostal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity creatine kinase activity nucleotide binding transferase activity, transferring phosphorus-containing groups catalytic activity ATP binding kinase activity Cellular component mitochondrial inner membrane membrane mitochondrion Biological process creatine metabolic process muscle contraction phosphorylation phosphocreatine biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1160 76722 Ensembl ENSG00000131730 ENSMUSG00000021622 UniProt P17540 Q6P8J7 RefSeq (mRNA) NM_001825 NM_001099735 NM_001099736 NM_198415 RefSeq (protein) NP_001093205 NP_001093206 NP_001816 NP_001093205.1 NP_001093206.1 NP_001816.2 NP_940807 Location (UCSC) Chr 5: 81.23 – 81.27 Mb Chr 13: 92 – 92.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. The "energy-rich" gamma-phosphate group of ATP that is generated by oxidative phosphorylation inside mitochondria is trans-phosphorylated to creatine (Cr) to give phospho-creatine (PCr), which then is exported from the mitochondria into the cytosol, where it is made available to cytosolic creatine kinases (CK) for in situ regeneration of the ATP that has been used for cellular work. Cr then is returning to the mitochondria where it stimulates mitochondrial respiration and again is charged-up by mitochondrial ATP via MtCK. This process is termed the PCr/Cr-shuttle or circuit. MtCK belongs to the creatine kinase (CK) isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Sarcomeric mitochondrial creatine kinase has 80% homology with the coding exons of ubiquitous mitochondrial creatine kinase. This gene contains sequences homologous to several motifs that are shared among some nuclear genes encoding mitochondrial proteins and thus may be essential for the coordinated activation of these genes during mitochondrial biogenesis.[6]