CKM (gene)

Creatine kinase, muscle also known as MCK is a creatine kinase that in humans is encoded by the MCK gene.[5]

CKM
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCKM, CKMM, M-CK, creatine kinase, M-type, CPK-M
External IDsOMIM: 123310 MGI: 88413 HomoloGene: 20432 GeneCards: CKM
Orthologs
SpeciesHumanMouse
Entrez

1158

12715

Ensembl

ENSG00000104879

ENSMUSG00000030399

UniProt

P06732

P07310

RefSeq (mRNA)

NM_001824

NM_007710

RefSeq (protein)

NP_001815

NP_031736

Location (UCSC)Chr 19: 45.31 – 45.32 MbChr 7: 19.14 – 19.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Structure

In the figure to the right, the crystal structure of the muscle-type M-CK monomer is shown. In vivo, two such monomers arrange symmetrically to form the active MM-CK enzyme.

Function

The protein encoded by this gene is a cytoplasmic enzyme involved in cellular energy homeostasis. The encoded protein reversibly catalyzes the transfer of "energy-rich" phosphate between ATP and creatine and between phospho-creatine and ADP. Its functional entity is a MM-CK homodimer in striated (sarcomeric) skeletal and cardiac muscle.

Clinical significance

In heart, in addition to the MM-CK homodimer, also the heterodimer MB-CK consisting of one muscle (M-CK) and one brain-type (B-CK) subunit is expressed. The latter may be an important serum marker for myocardial infarction, if released from damaged myocardial cells into the blood where it can be detected by clinical chemistry.

References

  1. GRCh38: Ensembl release 89: ENSG00000104879 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030399 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Rosenberg UB, Kunz G, Frischauf A, Lehrach H, Mähr R, Eppenberger HM, Perriard JC (November 1982). "Molecular cloning and expression during myogenesis of sequences coding for M-creatine kinase". Proc. Natl. Acad. Sci. U.S.A. 79 (21): 6589–92. Bibcode:1982PNAS...79.6589R. doi:10.1073/pnas.79.21.6589. PMC 347173. PMID 6959139.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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