CLDN19

Claudin-19 is a protein that in humans is encoded by the CLDN19 gene.[5] It belongs to the group of claudins. Claudin-19 has been implicated in magnesium transport.[6][7]

CLDN19
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCLDN19, HOMG5, claudin 19
External IDsOMIM: 610036 MGI: 3033992 HomoloGene: 17528 GeneCards: CLDN19
Orthologs
SpeciesHumanMouse
Entrez

149461

242653

Ensembl

ENSG00000164007

ENSMUSG00000066058

UniProt

Q8N6F1

Q9ET38

RefSeq (mRNA)

NM_148960
NM_001123395
NM_001185117

NM_001038590
NM_153105

RefSeq (protein)

NP_001116867
NP_001172046
NP_683763

NP_001033679
NP_694745

Location (UCSC)Chr 1: 42.73 – 42.74 MbChr 4: 119.11 – 119.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Claudins, such as CLDN19, are transmembrane proteins found at tight junctions. Tight junctions form barriers that control the passage of ions and molecules across an epithelial sheet and the movement of proteins and lipids between apical and basolateral domains of epithelial cells (Lee et al., 2006).[supplied by OMIM][5]

References

  1. GRCh38: Ensembl release 89: ENSG00000164007 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000066058 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CLDN19 claudin 19".
  6. Naeem, M.; Hussain, S.; Akhtar, N. (2011). "Mutation in the Tight-Junction Gene Claudin 19 (CLDN19) and Familial Hypomagnesemia, Hypercalciuria, Nephrocalcinosis (FHHNC) and Severe Ocular Disease". American Journal of Nephrology. 34 (3): 241–248. doi:10.1159/000330854. PMID 21791920.
  7. Konrad, M.; Schaller, A.; Seelow, D.; Pandey, A. V.; Waldegger, S.; Lesslauer, A.; Vitzthum, H.; Suzuki, Y.; Luk, J. M.; Becker, C.; Schlingmann, K. P.; Schmid, M.; Rodriguez-Soriano, J.; Ariceta, G.; Cano, F.; Enriquez, R.; Jüppner, H.; Bakkaloglu, S. A.; Hediger, M. A.; Gallati, S.; Neuhauss, S. C. F.; Nürnberg, P.; Weber, S. (2006). "Mutations in the Tight-Junction Gene Claudin 19 (CLDN19) Are Associated with Renal Magnesium Wasting, Renal Failure, and Severe Ocular Involvement". The American Journal of Human Genetics. 79 (5): 949–957. doi:10.1086/508617. PMC 1698561. PMID 17033971.

Further reading


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