CLDN5

Claudin-5 is a protein that in humans is encoded by the CLDN5 gene.[5][6][7] It belongs to the group of claudins.

CLDN5
Identifiers
AliasesCLDN5, AWAL, BEC1, CPETRL1, TMVCF, claudin 5, TMDVCF
External IDsOMIM: 602101 MGI: 1276112 HomoloGene: 2459 GeneCards: CLDN5
Orthologs
SpeciesHumanMouse
Entrez

7122

12741

Ensembl

ENSG00000184113

ENSMUSG00000041378

UniProt

O00501

O54942

RefSeq (mRNA)

NM_003277
NM_001130861
NM_001363066
NM_001363067

NM_013805

RefSeq (protein)

NP_001124333
NP_003268
NP_001349995
NP_001349996

NP_038833

Location (UCSC)Chr 22: 19.52 – 19.53 MbChr 16: 18.6 – 18.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome.[7]

Interactions

CLDN5 has been shown to interact with CLDN1[8] and CLDN3.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000184113 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000041378 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Peacock RE, Keen TJ, Inglehearn CF (December 1997). "Analysis of a human gene homologous to rat ventral prostate.1 protein". Genomics. 46 (3): 443–9. doi:10.1006/geno.1997.5033. PMID 9441748.
  6. Sirotkin H, Morrow B, Saint-Jore B, Puech A, Das Gupta R, Patanjali SR, Skoultchi A, Weissman SM, Kucherlapati R (Sep 1997). "Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome". Genomics. 42 (2): 245–51. doi:10.1006/geno.1997.4734. PMID 9192844.
  7. "Entrez Gene: CLDN5 claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)".
  8. Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG (Nov 2003). "Role of claudin interactions in airway tight junctional permeability". Am. J. Physiol. Lung Cell Mol. Physiol. 285 (5): L1166-78. doi:10.1152/ajplung.00182.2003. PMID 12909588.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.