CLDN7

Claudin-7 is a protein that in humans is encoded by the CLDN7 gene.[5][6] It belongs to the group of claudins.

CLDN7
Identifiers
AliasesCLDN7, CEPTRL2, CLDN-7, CPETRL2, Hs.84359, claudin-1, claudin 7
External IDsOMIM: 609131 MGI: 1859285 HomoloGene: 9649 GeneCards: CLDN7
Orthologs
SpeciesHumanMouse
Entrez

1366

53624

Ensembl

ENSG00000181885
ENSG00000288292

ENSMUSG00000018569

UniProt

O95471

Q9Z261

RefSeq (mRNA)

NM_001307
NM_001185022
NM_001185023

NM_001193619
NM_016887

RefSeq (protein)

NP_001171951
NP_001171952
NP_001298

NP_001180548
NP_058583

Location (UCSC)Chr 17: 7.26 – 7.26 MbChr 11: 69.86 – 69.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Claudins, such as CLDN7, are involved in the formation of tight junctions between epithelial cells. Tight junctions restrict lateral diffusion of lipids and membrane proteins, and thereby physically define the border between the apical and basolateral compartments of epithelial cells (Zheng et al., 2003).[supplied by OMIM][6]

References

  1. ENSG00000288292 GRCh38: Ensembl release 89: ENSG00000181885, ENSG00000288292 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000018569 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Morita K, Furuse M, Fujimoto K, Tsukita S (Mar 1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc Natl Acad Sci U S A. 96 (2): 511–6. Bibcode:1999PNAS...96..511M. doi:10.1073/pnas.96.2.511. PMC 15167. PMID 9892664.
  6. "Entrez Gene: CLDN7 claudin 7".

Further reading


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