CLEC1B

C-type lectin domain family 1 member B is a protein that in humans is encoded by the CLEC1B gene.[5][6][7]

CLEC1B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCLEC1B, 1810061I13Rik, CLEC2, CLEC2B, PRO1384, QDED721, C-type lectin domain family 1 member B
External IDsOMIM: 606783 MGI: 1913287 HomoloGene: 49468 GeneCards: CLEC1B
Orthologs
SpeciesHumanMouse
Entrez

51266

56760

Ensembl

ENSG00000165682

ENSMUSG00000030159

UniProt

Q9P126

Q9JL99

RefSeq (mRNA)

NM_001099431
NM_016509
NM_001393342

NM_001204239
NM_001204253
NM_019985

RefSeq (protein)

NP_001092901
NP_057593

NP_001191168
NP_001191182
NP_064369

Location (UCSC)Chr 12: 9.99 – 10.01 MbChr 6: 129.37 – 129.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells.[supplied by OMIM][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000165682 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030159 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Colonna M, Samaridis J, Angman L (Mar 2000). "Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells". Eur J Immunol. 30 (2): 697–704. doi:10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M. PMID 10671229.
  6. Sobanov Y, Bernreiter A, Derdak S, Mechtcheriakova D, Schweighofer B, Duchler M, Kalthoff F, Hofer E (Dec 2001). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex". Eur J Immunol. 31 (12): 3493–503. doi:10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9. PMID 11745369. S2CID 42415487.
  7. "Entrez Gene: CLEC1B C-type lectin domain family 1, member B".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.